Figure 1. Heat-shock proteins. (a) Domains in Hsp70 and Hsp40. (b) Interaction model of cochaperones in substrate binding.

Figure 2. Diverse cellular functions of AAA ⁺ proteins. Red, AAA proteins; blue, extended group of AAA ⁺ proteins. (After Ogura and Wilkinson, 2001.)

Figure 3. Ubiquitin–proteasome pathway.

Figure 4. Model for SCF E3 ligases.

Figure 5. Yeast regulatory network involving Rpn4.

Figure 6. Protein modification in yeast by SUMO.

Figure 7. UDPs in yeast. (After Buchberger, 2002.)

Figure 8. Families of yeast helicases. Dark blue, inserted sequences; FeS, iron–sulfur cluster; NTD, N-terminal domain; CTD, C-terminal domain; WH, winged helix domain; Zn, zinc finger domain.

Figure 9. Yeast helicases. (a) Conventional helicase binding motifs in superfamilies (Sf); not drawn to scale, insertions in helicase domains of some families neglected. (b) Consensus sequences in yeast Sf1 and Sf2 proteins; for Sf6, only MCM proteins are considered.

Figure 10. Composition of preribosome complexes. RNA helicases are highlighted in yellow.

Figure 11. Conserved motifs in monomeric DNA helicases. (a) Motifs in yeast Pif1p and Rrm3p shared with four other Pif-like helicases; amino acids in capitals are identical. Three additional motifs (in blue) are found inserted into the helicase. (b) Yeast Srs2p compared to other SF1 helicases; shown are motifs from Srs2p, with identical residues in the other helicases marked in red.

Figure 12. DNA repair and homologous recombination. BIR, break-induced replication; SSA, single-strand annealing; DSBR, double-strand break repair; SDSA, synthesis-dependent single-strand annealing. (After Marini and Krejci, 2010.)