Amyloids is a collective term to describe misfolded proteins that self-assemble into insoluble fibrils both in vitro and in vivo. These protein aggregates are involved in a wide variety of human diseases, from Alzheimer's Disease to Type 2 Diabetes and Rheumatoid Arthritis to Artherosclerosis. Given the importance of amyloids in a disease context, intense study of their biophysical properties has given plenty of new information on ways to inhibit their formation.
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Membrane remodeling by amyloid fibrils: Aggregation of the protein α-synuclein at the surface of negatively charged vesicle membrane results in the formation of membrane facets and lipid extraction.
Himanshu Chaudhary, Vinod Subramaniam, Mireille M. A. E. Claessens
ChemPhysChem, April 27, 2017, https://doi.org/10.1002/cphc.201700050 Read article
What is the main interaction site? The inhibitory mechanism of epigallocatechin gallate (EGCG) on fibrillation of human islet amyloid polypeptide (hIAPP)-NH2 was illustrated by experimental and computational methods. The hydrogen bonding and π–π interactions between the A ring of EGCG and residue Phe23 (see graphic, A) as well as the hydrophobic interaction between the A ring of EGCG and residue Ile26 (see graphic, B) are the main driving force of this inhibition process.
Zhi-Xue Xu, Gong-Li Ma, Qiang Zhang, Cong-Heng Chen, Yan-Ming He, Li-Hui Xu, Guang-Rong Zhou, Zhen-Hua Li, Hong-Jie Yang, Ping Zhou
ChemPhysChem, April 26, 2017, https://doi.org/10.1002/cphc.201700057 Read article
Pick up & break up: This study aimed at increasing the radical scavenging and anti-Aβ-aggregation activities of a series of benzylidenephenylpyrrolizinones. Some of the new derivatives showed promising results in this regard. These compounds could serve as a good starting point for new drugs to treat Alzheimer's disease.
Jean-Pierre Jourdan, Marc Since, Laïla El Kihel, Cédric Lecoutey, Sophie Corvaisier, Rémi Legay, Jana Sopková-de Oliveira Santos, Thierry Cresteil, Aurélie Malzert-Fréon, Christophe Rochais, Patrick Dallemagne
ChemMedChem, April 12, 2017, https://doi.org/10.1002/cmdc.201700102 Read article
Isr. J. Chem., February 03, 2017, https://doi.org/10.1002/ijch.201600097 Read article
Lingyun Zhang, Jeremy D. Schmit
Isr. J. Chem., January 30, 2017, https://doi.org/10.1002/ijch.201600079 Read article
Qinghua Liao, Michael C. Owen, Olujide O. Olubiyi, Bogdan Barz, Birgit Strodel
Isr. J. Chem., January 20, 2017, https://doi.org/10.1002/ijch.201600108 Read article
Kayla M. Pate, Regina M. Murphy
Isr. J. Chem., January 18, 2017, https://doi.org/10.1002/ijch.201600078 Read article
Cecilia Wallin, Jinghui Luo, Jüri Jarvet, Sebastian K. T. S. Wärmländer, Astrid Gräslund
Isr. J. Chem., December 28, 2016, https://doi.org/10.1002/ijch.201600105 Read article
Rehana Akter, Andisheh Abedini, Zachary Ridgway, Xiaoxue Zhang, Joel Kleinberg, Ann Marie Schmidt, Daniel P. Raleigh
Isr. J. Chem., December 19, 2016, https://doi.org/10.1002/ijch.201600081 Read article
Francesca Peccati, Stefano Pantaleone, Xavier Solans-Monfort, Mariona Sodupe
Isr. J. Chem., December 01, 2016, https://doi.org/10.1002/ijch.201600114 Read article
Rodrigo Aguayo-Ortiz, Laura Dominguez
Isr. J. Chem., November 25, 2016, https://doi.org/10.1002/ijch.201600073 Read article
Shira Shaham-Niv, Pavel Rehak, Lela Vuković, Lihi Adler-Abramovich, Petr Král, Ehud Gazit
Isr. J. Chem., November 16, 2016, https://doi.org/10.1002/ijch.201600076 Read article
Mingzhen Zhang, Baiping Ren, Hong Chen, Yan Sun, Jie Ma, Binbo Jiang, Jie Zheng
Isr. J. Chem., November 16, 2016, https://doi.org/10.1002/ijch.201600075 Read article
Kian Kamgar-Parsi, James Tolchard, Birgit Habenstein, Antoine Loquet, Akira Naito, Ayyalusamy Ramamoorthy
Isr. J. Chem., November 15, 2016, https://doi.org/10.1002/ijch.201600096 Read article
Jun Zhao, Buyong Ma, Ruth Nussinov
Isr. J. Chem., October 25, 2016, https://doi.org/10.1002/ijch.201600093 Read article
Mara Chiricotto, Thanh Thuy Tran, Phuong H. Nguyen, Simone Melchionna, Fabio Sterpone, Philippe Derreumaux
Isr. J. Chem., August 01, 2016, https://doi.org/10.1002/ijch.201600048 Read article