Hot TopicsWiley-VCH

Advanced Synthesis & CatalysisChemBioChemChemCatChemAngewandte


Using the catalytic power of enzymes to perform highly stereoselective organic transformations has been the basis of the ever-expanding field of biocatalysis. Enzymes have evolved over millions of years to be some of the best catalysts available to chemists. Now, through advances in molecular and synthetic biology, chemists are able to redesign the active sights of many enzymes to fit their synthetic needs.

The image by U. Bornscheuer et al. is from an article on the activity of a bacillus subtilis esterase, which appeared in a special issue of ChemCatChem on biocatalysis.

Find all articles on biocatalysis in Wiley Online Library...

Recent Articles

RSS feed

Integration of Enzymatic and Heterogeneous Catalysis for One-Pot Production of Fructose from Glucose

Integration of Enzymatic and Heterogeneous Catalysis for One‐Pot Production of Fructose from Glucose

Sugar gets sweeter: A one-pot, multistep selective procedure involving enzyme-catalyzed oxidation of glucose at C2 and Ni/C-catalyzed hydrogenation of d-glucosone at C1 gives fructose in 77 % yield. Fructose was also generated with similar efficiency and selectivity from α-cellulose and starch by using this combination of enzymatic and heterogeneous catalysis.

Jiankui Sun, Helong Li, Hongzhi Huang, Bo Wang, Ling-Ping Xiao, Guoyong Song
ChemSusChem, March 12, 2018, Read article

Lipase Encapsulation onto ZIF-8: A Comparison between Biocatalysts Obtained at Low and High Zinc/2-Methylimidazole Molar Ratio in Aqueous Medium

Lipase Encapsulation onto ZIF‐8: A Comparison between Biocatalysts Obtained at Low and High Zinc/2‐Methylimidazole Molar Ratio in Aqueous Medium

Low vs. high molar ratio: Rhizomucor miehei and Pseudomonas fluorescens lipases were encapsulated on ZIF-8 support by a “one-pot” aqueous synthesis. The effect of two different zinc/ligand molar ratios on enzyme loading and activity was investigated.

[Full Paper]
Federica Pitzalis, Cristina Carucci, Maryam Naseri, Lida Fotouhi, Edmond Magner, Andrea Salis
ChemCatChem, March 07, 2018, Read article

Size Does Matter—Mediation of Electron Transfer by Gold Clusters in Bioelectrocatalysis

Size Does Matter—Mediation of Electron Transfer by Gold Clusters in Bioelectrocatalysis

Size does matter: We report that redox activity of the gold nanoparticles may contribute to the ET mechanism of an enzyme, switching it to Au cluster mediated electron transfer between the active site and the electrode instead of direct ET as shown for fructose dehydrogenase. The presence gold clusters lead to the increase of catalytic reaction rate constant, kcat 2.5-fold and to a 100 mV reduction in the reaction overpotential.

Michal Kizling, Maciej Dzwonek, Agnieszka Więckowska, Renata Bilewicz
ChemCatChem, March 05, 2018, Read article

Whole-Cell Cascade Biotransformations for One-Pot Multistep Organic Synthesis

Whole‐Cell Cascade Biotransformations for One‐Pot Multistep Organic Synthesis

Bugs for Cascade Catalysis: Recombinant Escherichia coli is easily available and self-replicating whole-cell catalyst for biotransformations. Multiple enzymes could be co-expressed in a single E. coli host, thus enabling facile one-pot synthesis of valuable (chiral) products. In this paper, we reviewed the recent development, provided instruction, and discussed problems and solutions of whole-cell cascade biotransformations.

Shuke Wu, Zhi Li
ChemCatChem, February 23, 2018, Read article

Innovative Sol-Gel Routes for the Bottom-up Preparation of Heterogeneous Catalysts

Innovative Sol‐Gel Routes for the Bottom‐up Preparation of Heterogeneous Catalysts

Sol-gel chemistry is a resourceful toolbox for the preparation of advanced materials and this applies particularly to the design of advanced and tailored heterogeneous catalysts. By tweaking the classical sol-gel chemistry process it is possible to expand the scope of sol-gel routes and to yield new kinds of catalytic materials with remarkable properties and performance. This Personal Account exemplifies such strategies where one plays with the nature of the templating agent, the processing and drying conditions, the nature of the precursors or the nature of the solvent.

[Personal Account]
Damien P. Debecker
Chem. Rec., December 11, 2017, Read article

© Wiley-VCH 2016.