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Biocatalysis

Using the catalytic power of enzymes to perform highly stereoselective organic transformations has been the basis of the ever-expanding field of biocatalysis. Enzymes have evolved over millions of years to be some of the best catalysts available to chemists. Now, through advances in molecular and synthetic biology, chemists are able to redesign the active sights of many enzymes to fit their synthetic needs.

The image by U. Bornscheuer et al. is from an article on the activity of a bacillus subtilis esterase, which appeared in a special issue of ChemCatChem on biocatalysis.

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A Tandem Enzymatic sp2-C-Methylation Process: Coupling in Situ S-Adenosyl-L-Methionine Formation with Methyl Transfer

A Tandem Enzymatic sp2‐C‐Methylation Process: Coupling in Situ S‐Adenosyl‐L‐Methionine Formation with Methyl Transfer

A one-pot, two-enzyme C-methylation process is described. Combining SAM production using SalL (Salinospora tropica) with the C-methyltransferase NovO (Streptomyces spheroides) enables the synthesis of a suite of methylated and ethylated coumarin products, as demonstrated for labelled 13CH3, 13CD3 and CD3 groups from their corresponding SAM analogues.

[Communication]
Joanna C. Sadler, Luke D. Humphreys, Radka Snajdrova, Glenn A. Burley
ChemBioChem, April 27, 2017, https://doi.org/10.1002/cbic.201700115 Read article

Frontispiece: Electrochemical Investigations on the Inactivation of the [FeFe] Hydrogenase from Desulfovibrio desulfuricans by O2 or Light under Hydrogen-Producing Conditions

Frontispiece: Electrochemical Investigations on the Inactivation of the [FeFe] Hydrogenase from Desulfovibrio desulfuricans by O2 or Light under Hydrogen‐Producing Conditions

The frontispiece shows the [FeFe] hydrogenase from Desulfovibrio desulfuricans on an electrode under conditions that produce H2. At low potentials, the enzyme accumulates enough electrons at the FeS clusters to reduce O2 into H2O, thereby avoiding formation of harmful intermediates. These conditions also favor the light-stable reduced states of the enzyme making it an ideal candidate for solar-to-hydrogen devices. Details are given in the Communication by O. Rüdiger and co-workers on page 540.

[Frontispiece]
Patricia Rodríguez-Maciá, James A. Birrell, Wolfgang Lubitz, Olaf Rüdiger
ChemPlusChem, April 20, 2017, https://doi.org/10.1002/cplu.201780461 Read article

Back Cover: Quo Vadis, Implanted Fuel Cell? (ChemPlusChem 4/2017)

Back Cover: Quo Vadis, Implanted Fuel Cell? (ChemPlusChem 4/2017)

The cover picture shows the road towards safe and effective implantable electrical power devices. Although the goal of “personal electricity” has not yet been reached, a significant amount of scientific and technological progress has already been made through various approaches including implanted fuel cells. Details are given in the Minireview by S. Shleev on page 522 in Issue 4, 2017 (DOI: 10.1002/cplu.201600536).

[Cover Picture]
Sergey Shleev
ChemPlusChem, March 09, 2017, https://doi.org/10.1002/cplu.201700112 Read article

Application of Biocatalysis to on-DNA Carbohydrate Library Synthesis

Application of Biocatalysis to on‐DNA Carbohydrate Library Synthesis

Cracking the codes: Biocatalysis is particularly beneficial for DNA-encoded libraries, as it is highly selective and can be performed in aqueous environments. In this work, we demonstrated the application of biocatalysis for the on-DNA synthesis of carbohydrate-based libraries by using enzymatic oxidation and glycosylation in combination with traditional organic chemistry.

[Communication]
Baptiste Thomas, Xiaojie Lu, William R. Birmingham, Kun Huang, Peter Both, Juana Elizabeth Reyes Martinez, Robert J. Young, Christopher P. Davie, Sabine L. Flitsch
ChemBioChem, February 28, 2017, https://doi.org/10.1002/cbic.201600678 Read article

Quo Vadis, Implanted Fuel Cell?

Quo Vadis, Implanted Fuel Cell?

Personal power: The road to safe and effective implantable electrical power devices has been long—and the goal has not been reached yet, although significant scientific and technological progress has been made. This Review highlights stages in the development of implanted fuel cells capable of providing electrical power for running implanted “personal electronics”.

[Minireview]
Sergey Shleev
ChemPlusChem, January 31, 2017, https://doi.org/10.1002/cplu.201600536 Read article

Electrochemical Investigations on the Inactivation of the [FeFe] Hydrogenase from Desulfovibrio desulfuricans by O2 or Light under Hydrogen-Producing Conditions

Electrochemical Investigations on the Inactivation of the [FeFe] Hydrogenase from Desulfovibrio desulfuricans by O2 or Light under Hydrogen‐Producing Conditions

Save the sun for later: It is shown how the extremely active [FeFe] hydrogenase from Desulfovibrio desulfuricans can reduce protons to H2 in the presence of limited amounts of O2 at low potentials (see figure). Furthermore, the robustness of this enzyme under illumination is demonstrated. These studies together show that this hydrogenase is an excellent candidate for use in solar-to-hydrogen devices.

[Communication]
Patricia Rodríguez-Maciá, James A. Birrell, Wolfgang Lubitz, Olaf Rüdiger
ChemPlusChem, November 03, 2016, https://doi.org/10.1002/cplu.201600508 Read article

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