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Drug Delivery

The importance of drug delivery to chemists, medicinal and otherwise, has increased since the advent of integrated drug discovery processes. Physicochemical and biological barriers, pathways for drug delivery, formulation, pharmacokinetic and pharmacodynamic issues, metabolism, and cell culture models used in studying drug delivery are just some of the topics that make drug delivery an exciting field for researchers.

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Nanoformulation of Brain-Derived Neurotrophic Factor with Target Receptor-Triggered-Release in the Central Nervous System

Nanoformulation of Brain‐Derived Neurotrophic Factor with Target Receptor‐Triggered‐Release in the Central Nervous System

A self-assembled nanoformulation delivers active brain-derived neurotrophic factor (BDNF) to the central nervous system via the intranasal-to-brain pathway. The polyion complex formed by electrostatic interactions between BDNF and poly(ethylene glycol)-b-poly(l-glutamic acid) stabilizes the protein and delivers it to the brain at significantly higher rates than the native protein, and releases BDNF exclusively to its receptors upon contact.

[Full Paper]
Yuhang Jiang, James M. Fay, Chi-Duen Poon, Natasha Vinod, Yuling Zhao, Kristin Bullock, Si Qin, Devika S Manickam, Xiang Yi, William A. Banks, Alexander V. Kabanov
Adv. Funct. Mater., December 07, 2017, https://doi.org/10.1002/adfm.201703982 Read article

Dimeric Drug Polymeric Micelles with Acid-Active Tumor Targeting and FRET-Traceable Drug Release

Dimeric Drug Polymeric Micelles with Acid‐Active Tumor Targeting and FRET‐Traceable Drug Release

A dimeric drug polymeric micelle with acid-active tumor targeting and Förster resonance energy transfer (FRET)-traceable drug release is successfully fabricated. It has such unique features as long blood circulation through shielding of the cationic charges of trans-activating transcriptional activator (TAT), enhanced cellular internalization by regenerating the original TAT in acidic tumor tissue, and intracellular glutathione-triggered FRET-traceable drug release.

[Communication]
Xing Guo, Lin Wang, Kayla Duval, Jing Fan, Shaobing Zhou, Zi Chen
Adv. Mater., December 06, 2017, https://doi.org/10.1002/adma.201705436 Read article

Emerging Roles of Electrospun Nanofibers in Cancer Research

Emerging Roles of Electrospun Nanofibers in Cancer Research

The application of electrospun nanofibers in cancer research, including drug/gene delivery, 3D cancer model, cancer cell detection/sensing, cancer cell imaging, cancer cell capture/separation/isolation, regulating the behavior of cancer cells, and engineering the pre-metastatic niche is reviewed in this progress report.

[Progress Report]
Shixuan Chen, Sunil Kumar Boda, Surinder K. Batra, Xiaoran Li, Jingwei Xie
Adv. Healthcare Mater., December 06, 2017, https://doi.org/10.1002/adhm.201701024 Read article

Iron Oxide Nanoparticles: Innovative Tool in Cancer Diagnosis and Therapy

Iron Oxide Nanoparticles: Innovative Tool in Cancer Diagnosis and Therapy

Cancer represents one of the most dangerous diseases of present days and research for the most innovative and noninvasive diagnostic, and therapeutic methods is a contemporary issue since the current medical approaches are not complying with the development of the disease. Magnetic nanoparticles fulfill a demanding need in this clinical area and should be integrated into practice.

[Review]
Pavla Martinkova, Martin Brtnicky, Jindrich Kynicky, Miroslav Pohanka
Adv. Healthcare Mater., December 04, 2017, https://doi.org/10.1002/adhm.201700932 Read article

Dynamic and Responsive Growth Factor Delivery from Electrospun and Hydrogel Tissue Engineering Materials

Dynamic and Responsive Growth Factor Delivery from Electrospun and Hydrogel Tissue Engineering Materials

Tissue engineering materials need to be able to provide ongoing structural support as well as dynamically controlled drug delivery for optimal therapeutic outcomes. Electrospun and hydrogel materials are popular tissue engineering scaffolds for providing structural support, and this Progress Report explores the pros and cons of different drug delivery systems being developed for use in these materials.

[Progress Report]
Kiara F. Bruggeman, Richard J. Williams, David R. Nisbet
Adv. Healthcare Mater., November 30, 2017, https://doi.org/10.1002/adhm.201700836 Read article

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

Predetermining the biological outcome of nanomaterials by design is essential for safe and effective biomedical applications. In this Review, it is chronicled that how the nanomaterial design of pure silica, partially hybridized organosilica, and fully hybridized organosilica governs not only their physico-chemical properties but also their biocompatibility, protein corona, biodistribution, biodegradability, and clearance. Cargo loading/delivery strategies and trending biomedical applications are also discussed.

[Review]
Jonas G. Croissant, Yevhen Fatieiev, Abdulaziz Almalik, Niveen M. Khashab
Adv. Healthcare Mater., November 30, 2017, https://doi.org/10.1002/adhm.201700831 Read article

Cell-Based Drug Delivery and Use of Nano-and Microcarriers for Cell Functionalization

Cell‐Based Drug Delivery and Use of Nano‐and Microcarriers for Cell Functionalization

A fresh outlook in advances for design of cell-based drug vehicles as biological transporter platform for targeted delivery of different drugs is presented in this progress report. An overview of the current strategies of cell functionalization by nano- and microcarriers are provided for the first time. Then, animal models for studying cell assisted drug delivery are discussed.

[Progress Report]
Alexander S. Timin, Maxim M. Litvak, Dmitry A. Gorin, Elena N. Atochina-Vasserman, Dmitriy N. Atochin, Gleb B. Sukhorukov
Adv. Healthcare Mater., November 30, 2017, https://doi.org/10.1002/adhm.201700818 Read article

Comparison of Carbazole and Fluorene Donating Effects on the Two-Photon Absorption and Nitric Oxide Photorelease Capabilities of a Ruthenium–Nitrosyl Complex

Comparison of Carbazole and Fluorene Donating Effects on the Two‐Photon Absorption and Nitric Oxide Photorelease Capabilities of a Ruthenium–Nitrosyl Complex

Replacing a fluorene by a more donating carbazole unit in a ruthenium–nitrosyl complex leads to a decrease in the quantum yield of NO photorelease from 0.03 to 0.01, and to an increase in the two-photon cross-section from 108 to 159 GM. This raises the issue of the optimization of the donating/withdrawing effect on the encaging cross-section.

[Full Paper]
Alejandro Enriquez-Cabrera, Pascal G. Lacroix, Isabelle Sasaki, Sonia Mallet-Ladeira, Norberto Farfán, Rodrigo M. Barba-Barba, Gabriel Ramos-Ortiz, Isabelle Malfant
Eur. J. Inorg. Chem., November 29, 2017, https://doi.org/10.1002/ejic.201700895 Read article

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

The awareness of the physical–chemical characteristics of poly(lactic-co-glycolic) acid, all of its potential and pitfalls, either alone or upon conjugation/functionalization with other polymers and molecules, opens new avenues in its application in the biomedical field, especially in drug delivery and tissue regeneration.

[Review]
Cláudia Martins, Flávia Sousa, Francisca Araújo, Bruno Sarmento
Adv. Healthcare Mater., November 24, 2017, https://doi.org/10.1002/adhm.201701035 Read article

Gold Nanorods with Silica Shell and PAMAM Dendrimers for Efficient Photothermal Therapy and Low Toxic Codelivery of Anticancer Drug and siRNA

Gold Nanorods with Silica Shell and PAMAM Dendrimers for Efficient Photothermal Therapy and Low Toxic Codelivery of Anticancer Drug and siRNA

The AuNRs@SiO2-G3 nanocomposites with uniform size and excellent stability are prepared by grafting polyamidoamine dendrimers up to third generation onto the surface of mesoporous silica-coated gold nanorods (AuNRs@SiO2) via a divergent technique. They show great potential to be used as a multifunctional nanoplatform to improve photothermal effect with the complement of gene silencing and chemotherapy, which may provide new possibilities for cancer treatment.

[Full Paper]
Qianyu Zhang, Li Wang, Yajun Jiang, Wei Gao, Yinsong Wang, Xiaoying Yang, Xinlin Yang, Zunfeng Liu
Adv. Mater. Interfaces, November 09, 2017, https://doi.org/10.1002/admi.201701166 Read article

Iterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems

Iterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems

A simple photochemical iterative procedure tackles the challenge of polymers multifunctionalization for biomedical applications.

[Communication]
Assala Al Samad, Audrey Bethry, Olga Janouskova, Jérémie Ciccione, Christiane Wenk, Jean-Luc Coll, Gilles Subra, Tomas Etrych, Fawaz El Omar, Youssef Bakkour, Jean Coudane, Benjamin Nottelet
Macromol. Rapid Commun., November 02, 2017, https://doi.org/10.1002/marc.201700502 Read article

Rational Design of a New Self-Codelivery System from Redox-Sensitive Camptothecin–Cytarabine Conjugate Assembly for Effectively Synergistic Anticancer Therapy

Rational Design of a New Self‐Codelivery System from Redox‐Sensitive Camptothecin–Cytarabine Conjugate Assembly for Effectively Synergistic Anticancer Therapy

Based on the therapy drawbacks of individual camptothecin (CPT) or Ara-C anticancer drug, CPT and Ara-C are cleverly conjugated together through a disulfide bond to construct a redox-sensitive drug–drug conjugate for realizing an “all-in-one” carrier-free drug codelivery system to overcome the drawbacks of individual CPT or Ara-C for cancer therapy.

[Full Paper]
Wenxiu He, Xu Hu, Wei Jiang, Ruiling Liu, Di Zhang, Jing Zhang, Zhonghao Li, Yuxia Luan
Adv. Healthcare Mater., October 27, 2017, https://doi.org/10.1002/adhm.201700829 Read article

Polymer Nanoassembly as Delivery Systems and Anti-Bacterial Toolbox: From PGMAs to MSN@PGMAs

Polymer Nanoassembly as Delivery Systems and Anti‐Bacterial Toolbox: From PGMAs to MSN@PGMAs

This Account introduces our research progress of drug delivery systems based on PGMA nanoparticles and nanoassemblies for the delivery of model molecules and therapeutic agents. Importantly, MSN@PGMAs based on atom transfer radical polymerization assisted systems, host-guest interaction assisted systems, and layer-by-layer self-assembled systems as well as the potential bioapplications and anti-bacterial applications of these nanocarriers are then discussed. Finally, the challenges and development directions of such nanoplatforms are brought out.

[Personal Account]
Ming-Xue Wu, Xin Wang, Ying-Wei Yang
Chem. Rec., July 04, 2017, https://doi.org/10.1002/tcr.201700036 Read article

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