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RNA

RNA, RNA interference, ribozyme switches, microRNA, structural studies, aptamers, and more ...

The importance of RNA interference was recognized by the Nobel Assembly, who awarded the 2006 Nobel Prize in Physiology or Medicine jointly to Andrew Z. Fire (Stanford School of Medicine, USA) and Craig C. Mello (University of Massachusetts, USA) for their discovery of RNA interference—gene silencing by double-stranded RNA.

Thomas Tuschl, winner of the Wiley Prize in Biomedical Sciences in 2003, discussed RNA Interference and Small Interfering RNAs in a Minireview in ChemBioChem, 2001, 2, 239.

Find all articles on RNA or just on RNA interference in Wiley Online Library...

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Synthesis and Multiple Incorporations of 2′-O-Methyl-5-hydroxymethylcytidine, 5-Hydroxymethylcytidine and 5-Formylcytidine Monomers into RNA Oligonucleotides

Synthesis and Multiple Incorporations of 2′‐O‐Methyl‐5‐hydroxymethylcytidine, 5‐Hydroxymethylcytidine and 5‐Formylcytidine Monomers into RNA Oligonucleotides

Siting cytidine: 2′-O-Methyl-5-hydroxymethylcytidine (hm5Cm), 5-hydroxymethylcytidine (hm5C) and 5-formylcytidine (f5C) phosphoramidite monomers have been synthesised and incorporated into RNA oligonucleotides. Optimisation of the mild post-synthetic deprotection conditions enabled the preparation of RNA oligomers containing several of one of the cytosine modifications or a combination of four.

[Communication]
Arun A. Tanpure, Shankar Balasubramanian
ChemBioChem, October 09, 2017, https://doi.org/10.1002/cbic.201700492 Read article

Photo-Induced Charge-Variable Conjugated Polyelectrolyte Brushes Encapsulating Upconversion Nanoparticles for Promoted siRNA Release and Collaborative Photodynamic Therapy under NIR Light Irradiation

Photo‐Induced Charge‐Variable Conjugated Polyelectrolyte Brushes Encapsulating Upconversion Nanoparticles for Promoted siRNA Release and Collaborative Photodynamic Therapy under NIR Light Irradiation

Photo-induced charge-variable conjugated polyelectrolyte brushes encapsulating upconversion nanoparticle (UCNP@CCPEB) is fabricated for promoted small interfering RNA (siRNA) release and collaborative photodynamic therapy under NIR light irradiation. UCNP@CCPEB with good stability and excellent siRNA-loading capacity exhibit good 1O2 production and promote siRNA release under 980 nm irradiation which induces highly effective collaborative tumor therapy in vitro and in vivo.

[Full Paper]
Hui Zhao, Wenbo Hu, Hengheng Ma, Rongcui Jiang, Yufu Tang, Yu Ji, Xiaomei Lu, Bing Hou, Weixing Deng, Wei Huang, Quli Fan
Adv. Funct. Mater., October 06, 2017, https://doi.org/10.1002/adfm.201702592 Read article

Specific and Direct Amplified Detection of MicroRNA with MicroRNA:Argonaute-2 Cleavage (miRACle) Beacons

Specific and Direct Amplified Detection of MicroRNA with MicroRNA:Argonaute‐2 Cleavage (miRACle) Beacons

Simple sensors simulate substrate: MicroRNA detection with molecular beacons can be used for in situ genetic profiling. Beacons that are susceptible to the endogenous nuclease Argonaute-2 (Ago2) have now been developed. After purification of the complex by co-immunoprecipitation, microRNA:Ago2 cleavage (miRACle) beacons undergo site- and sequence-specific cleavage, and show a 13-fold fluorescence enhancement over traditional beacons.

[Communication]
Benjamin M. Luby, Gang Zheng
Angew. Chem. Int. Ed., September 27, 2017, https://doi.org/10.1002/anie.201707366 Read article

Polyamine-Mediated Stoichiometric Assembly of Ribonucleoproteins for Enhanced mRNA Delivery

Polyamine‐Mediated Stoichiometric Assembly of Ribonucleoproteins for Enhanced mRNA Delivery

Although numerous carriers have been developed for mRNA delivery, the inefficient mRNA expression inside cells remains a major challenge. Inspired by the dependence of mRNA on 3′-terminal polyadenosine nucleotides (poly A) and poly A binding proteins (PABPs) for optimal expression, synthetic mRNA containing a poly A tail was complexed with PABPs in a stoichiometric manner.

[Communication]
Jiahe Li, Yanpu He, Wade Wang, Connie Wu, Celestine Hong, Paula T. Hammond
Angew. Chem. Int. Ed., September 19, 2017, https://doi.org/10.1002/anie.201707466 Read article

Glycan Stimulation Enables Purification of Prostate Cancer Circulating Tumor Cells on PEDOT NanoVelcro Chips for RNA Biomarker Detection

Glycan Stimulation Enables Purification of Prostate Cancer Circulating Tumor Cells on PEDOT NanoVelcro Chips for RNA Biomarker Detection

A glycan-stimulated and poly(3,4-ethylene-dioxythiophene) (PEDOT)-based nanomaterial platform is fabricated to purify circulating tumor cells. This PEDOT NanoVelcro chip not only provides highly efficient and specific capture of cancer cells but also enables competitive binding of glycan with higher affinity (i.e., sorbitol) to release them. Cancer cells purified are further utilized to correlate disease-related RNA biomarkers in prostate cancer patients.

[Communication]
Mo-Yuan Shen, Jie-Fu Chen, Chun-Hao Luo, Sangjun Lee, Cheng-Hsuan Li, Yung-Ling Yang, Yu-Han Tsai, Bo-Cheng Ho, Li-Rong Bao, Tien-Jung Lee, Yu Jen Jan, Ya-Zhen Zhu, Shirley Cheng, Felix Y. Feng, Peilin Chen, Shuang Hou, Vatche Agopian, Yu-Sheng Hsiao, Hsian-Rong Tseng, Edwin M. Posadas, Hsiao-hua Yu
Adv. Healthcare Mater., September 11, 2017, https://doi.org/10.1002/adhm.201700701 Read article

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