RNA, RNA interference, ribozyme switches, microRNA, structural studies, aptamers, and more ...
The importance of RNA interference was recognized by the Nobel Assembly, who awarded the 2006 Nobel Prize in Physiology or Medicine jointly to Andrew Z. Fire (Stanford School of Medicine, USA) and Craig C. Mello (University of Massachusetts, USA) for their discovery of RNA interference—gene silencing by double-stranded RNA.
Thomas Tuschl, winner of the Wiley Prize in Biomedical Sciences in 2003, discussed RNA Interference and Small Interfering RNAs in a Minireview in ChemBioChem, 2001, 2, 239.
Ultrasound responsive nanodroplets offer advantages over other delivery agents in terms of their ability to penetrate tumor tissue. Successful delivery of siRNA to both lung and breast cancer cell lines is demonstrated with no degradation of the therapeutic. In addition, magnetic targeting of the droplets and correlation between therapeutic effect and the energy of acoustic emissions are shown.
Jeong Yu Lee, Calum Crake, Boon Teo, Dario Carugo, Marie de Saint Victor, Anjali Seth, Eleanor Stride
Adv. Healthcare Mater., February 13, 2017, DOI: 10.1002/adhm.201601246. Read article
Long live RNA! Keeping RNA in pullulan films can lengthen the lifespan of an RNA molecule, and can be used on demand as these films can readily dissolve in aqueous solutions.
Ping-Yao Hsieh, M. Monsur Ali, Kha Tram, Sana Jahanshahi-Anbuhi, Christine L. Brown, John D. Brennan, Carlos D. M. Filipe, Yingfu Li
ChemBioChem, February 08, 2017, DOI: 10.1002/cbic.201600643. Read article
Inspiring self-destruction: CGlcN6P induces the self-cleavage of the glmS ribozyme. This leads to degradation of the glmS mRNA and, consequently, to a reduction of the GlmS enzyme. As the enzyme is essential, this eventually causes inhibition of bacterial growth.
Anna Schüller, Daniel Matzner, Christina E. Lünse, Valentin Wittmann, Catherine Schumacher, Sandra Unsleber, Heike Brötz-Oesterhelt, Christoph Mayer, Gabriele Bierbaum, Günter Mayer
ChemBioChem, January 30, 2017, DOI: 10.1002/cbic.201600491. Read article
For the chronic implantable peripheral nerve cuff electrode, compensating for the electrical properties of a miniaturized electrode and ensuring its biocompatibility so that it can maintain its functionality are paramount considerations and inevitable challenges. The cuff electrode with Pt black/Nafion exhibits some very important biofunctionality and biocompatibility, which are demonstrated by in vivo histological analysis and mRNA gene expression alteration.
Yi Jae Lee, Han-Jun Kim, Ji Yoon Kang, Sun Hee Do, Soo Hyun Lee
Adv. Healthcare Mater., January 16, 2017, DOI: 10.1002/adhm.201601022. Read article
Mol. Inf., December 21, 2016, DOI: 10.1002/minf.201600132. Read article