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RNA

RNA, RNA interference, ribozyme switches, microRNA, structural studies, aptamers, and more ...

The importance of RNA interference was recognized by the Nobel Assembly, who awarded the 2006 Nobel Prize in Physiology or Medicine jointly to Andrew Z. Fire (Stanford School of Medicine, USA) and Craig C. Mello (University of Massachusetts, USA) for their discovery of RNA interference—gene silencing by double-stranded RNA.

Thomas Tuschl, winner of the Wiley Prize in Biomedical Sciences in 2003, discussed RNA Interference and Small Interfering RNAs in a Minireview in ChemBioChem, 2001, 2, 239.

Find all articles on RNA or just on RNA interference in Wiley Online Library...

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Graphene Oxide Conjugated Magnetic Beads for RNA Extraction

Graphene Oxide Conjugated Magnetic Beads for RNA Extraction

Magnets! A magnetic material that consists of silica-coated magnetic beads conjugated with graphene oxide (GO) was prepared. The material was tested in the separation of ribonucleic acid (RNA) in a lysed cell, and the results show that the GO-modified magnetic beads can be used as mobile solid-phase particle candidates, and used to directly separate the RNA in biomaterials.

[Communication]
Xuan-Hung Pham, Ahruem Baek, Tae Han Kim, Sang Hun Lee, Won-Yeop Rho, Woo-Jae Chung, Dong-Eun Kim, Bong-Hyun Jun
Chem. Asian J., June 22, 2017, https://doi.org/10.1002/asia.201700554 Read article

Multifunctional Molecular Beacon Micelles for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug-Resistant Cancer Cells

Multifunctional Molecular Beacon Micelles for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug‐Resistant Cancer Cells

Molecular beacon-based micelle system (a-MBM) presents its capability to combat multidrug resistance (MDR) in a sequential and synergistic way. With enhanced enzymatic stability, excellent target selectivity, and high drug-loading capacity, a-MBMs allows for visualization of MDR1 mRNA and specifically inhibits MDR1 gene expression. It also results in a high chemotherapeutic efficacy because of successful restoration of drug sensitivity.

[Full Paper]
Ruili Zhang, Shi Gao, Zhongliang Wang, Da Han, Lin Liu, Qingjie Ma, Weihong Tan, Jie Tian, Xiaoyuan Chen
Adv. Funct. Mater., May 30, 2017, https://doi.org/10.1002/adfm.201701027 Read article

Conformational Dynamics of mRNA in Gene Expression as New Pharmaceutical Target

Conformational Dynamics of mRNA in Gene Expression as New Pharmaceutical Target

Recent functional studies demonstrate the importance of mRNA conformational dynamics in the regulation of gene expression and protein function. The structure, stability, and kinetic properties of nucleic acids are sensitive to the intracellular molecular environment, such as the concentrations of molecular crowding agents and molecules that interact with mRNA. Here, we review the roles of mRNA conformational dynamics in consecutive and concurrent processes involved in gene expression and discuss the possibility of using nucleic acid conformational dynamics as a basis of pharmaceutical drug development.

[Personal Account]
Tamaki Endoh, Naoki Sugimoto
Chem. Rec., May 17, 2017, https://doi.org/10.1002/tcr.201700016 Read article

Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide

Arginine‐Rich Peptide‐Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide

T-cell immunity elicited by mRNA vaccines is heavily influenced by the delivery system. Cell penetrating peptide containing amphipathic RALA motifs condenses mRNA into nanocomplexes that efficiently translocate their mRNA cargo from endocytic vesicles to the cytosol. Through unique immune activation and enhanced expression, nucleoside modified mRNA complexed with RALA peptide induces potent antigen specific cytolytic T cells in vivo.

[Full Paper]
Vimal K. Udhayakumar, Ans De Beuckelaer, Joanne McCaffrey, Cian M. McCrudden, Jonathan L. Kirschman, Daryll Vanover, Lien Van Hoecke, Kenny Roose, Kim Deswarte, Bruno G. De Geest, Stefan Lienenklaus, Philip J. Santangelo, Johan Grooten, Helen O. McCarthy, Stefaan De Koker
Adv. Healthcare Mater., April 24, 2017, https://doi.org/10.1002/adhm.201601412 Read article

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