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RNA, RNA interference, ribozyme switches, microRNA, structural studies, aptamers, and more ...
The importance of RNA interference was recognized by the Nobel Assembly, who awarded the 2006 Nobel Prize in Physiology or Medicine jointly to Andrew Z. Fire (Stanford School of Medicine, USA) and Craig C. Mello (University of Massachusetts, USA) for their discovery of RNA interference—gene silencing by double-stranded RNA.
Thomas Tuschl, winner of the Wiley Prize in Biomedical Sciences in 2003, discussed RNA Interference and Small Interfering RNAs in a Minireview in ChemBioChem, 2001, 2, 239.
Find all articles on RNA or just on RNA interference in Wiley Online Library...
Chasing tails: A PNA oligomer containing a new microenvironment-sensitive fluorescent PNA base analogue, obtained by attaching the Lucifer chromophore (1,8-naphthalimide) at the 5-position of uracil, serves as a robust imaging tool for cellular poly(A) RNAs.
[Full Paper]
Pramod M. Sabale, Uddhav B. Ambi, Seergazhi G. Srivatsan
ChemBioChem, March 13, 2018, https://doi.org/10.1002/cbic.201700661 Read article
Flexing 'plexes: A new fluorescent probe, QUMA-1, for the selective, continuous, and real-time imaging of RNA G-quadruplexes in live cells is reported. The use of QUMA-1 in previously inaccesible applications, including live-cell imaging of RNA G-quadruplex dynamics and the visualization of the unwinding of RNA G-quadruplexes by RNA helicase is demonstrated.
[Communication]
Xiu-Cai Chen, Shuo-Bin Chen, Jing Dai, Jia-Hao Yuan, Tian-Miao Ou, Zhi-Shu Huang, Jia-Heng Tan
Angew. Chem. Int. Ed., March 13, 2018, https://doi.org/10.1002/anie.201801999 Read article
Adjustable fluidic nanomixing is used to enable rapid universal detection of various RNA types without target amplification. Alterable alternating current electrohydrodynamic nanomixing and direct detection of native RNA targets is achieved on an integrated nanodevice. Multi-RNA-type profiling is performed in cancer patient samples to showcase the promise for noninvasive clinical diagnosis, prognosis, and treatment monitoring.
[Full Paper]
Kevin M. Koo, Shuvashis Dey, Matt Trau
Small, March 12, 2018, https://doi.org/10.1002/smll.201704025 Read article
A pH-responsive dissociable and size/charge changeable micelleplex with enhanced tumor penetration is developed for photodynamic immunotherapy (PDT). It blocks PD-1/programmed death-ligand 1 (PD-L1) interaction-mediated immune evasion and stimulates PDT-initiated immune response. The micelleplex system significantly inhibits tumor growth via combined effects of PDT-induced antitumor immune response and RNAi-mediated PD-L1 blockade with high efficiency in vivo.
[Full Paper]
Liangliang Dai, Ke Li, Menghuan Li, Xiaojing Zhao, Zhong Luo, Lu Lu, Yanfeng Luo, Kaiyong Cai
Adv. Funct. Mater., March 08, 2018, https://doi.org/10.1002/adfm.201707249 Read article
Inspired by intracellular protein–nucleic acid binding events that often occur at nanoscale biointerface, here a high-performance trans-scale functional interface capable of considerably enhancing in vitro DNA-enzyme interaction is reported. The high-curvature nanostructuring surface affords high probe density and absolute molecular numbers, accelerates interfacial biomolecular diffusions, allows probe molecules to be easily accessible, and enables ultrasensitive detection of miRNA.
[Full Paper]
Lei Ye, Fan Yang, Yuanlin Ding, Haibin Yu, Lin Yuan, Qi Dai, Yujie Sun, Xiaoxue Wu, Yang Xiang, Guo-Jun Zhang
Adv. Funct. Mater., March 01, 2018, https://doi.org/10.1002/adfm.201706981 Read article
The initial transition from fatty acid membranes (gray) to phospholipid membranes (purple) in primitive cells may have been facilitated by the properties of membranes composed of both amphiphiles. Such hybrid membranes achieve high stability to divalent cations while maintaining permeability to small charged molecules, thus allowing critical chemical reactions to proceed within primitive cells.
[Full Paper]
Lin Jin, Neha P. Kamat, Siddhartha Jena, Jack W. Szostak
Small, February 26, 2018, https://doi.org/10.1002/smll.201704077 Read article
RNA-templated concatenation: A trinucleotide γ-peptide nucleic acid containing a C-terminal thioester and an N-terminal cystine undergoes RNA-templated concatenation upon reduction of the disulfide bond and self-deactivation (intramolecular cyclization) in the absence of an RNA target. MPγPNA=miniPEG-γ-peptide nucleic acid.
[Communication]
Raman Bahal, Arunava Manna, Wei-Che Hsieh, Shivaji A. Thadke, Gopalsamy Sureshkumar, Danith H. Ly
ChemBioChem, February 12, 2018, https://doi.org/10.1002/cbic.201700574 Read article
Back to the beginning: The relatively low chemical stability of cytosine compared with other nucleobases is a key concern in origin-of-life scenarios, but the effect of pressure on the rate of hydrolysis of cytosine to uracil has remained unknown. At high (200 MPa) pressures, the half-life of cytosine at 100 °C is halved to 8.6 days compared with that at ambient pressure.
[Communication]
Christopher P. Lepper, Martin A. K. Williams, David Penny, Patrick J. B. Edwards, Geoffrey B. Jameson
ChemBioChem, February 06, 2018, https://doi.org/10.1002/cbic.201700555 Read article
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