RNA, RNA interference, ribozyme switches, microRNA, structural studies, aptamers, and more ...
The importance of RNA interference was recognized by the Nobel Assembly, who awarded the 2006 Nobel Prize in Physiology or Medicine jointly to Andrew Z. Fire (Stanford School of Medicine, USA) and Craig C. Mello (University of Massachusetts, USA) for their discovery of RNA interference—gene silencing by double-stranded RNA.
Thomas Tuschl, winner of the Wiley Prize in Biomedical Sciences in 2003, discussed RNA Interference and Small Interfering RNAs in a Minireview in ChemBioChem, 2001, 2, 239.
To mimic cellular multienzyme complexes, enzymes have been attached to templates such as proteins and lipid bilayers in a manner suitable for cascade processes. DNA and RNA nanostructures were recently also shown to be promising templates for such processes. Here we highlight recent advances in nucleic-acid-templated substrate-transfer systems and discusses future perspectives.
Arivazhagan Rajendran, Eiji Nakata, Shun Nakano, Takashi Morii
ChemBioChem, March 22, 2017, https://doi.org/10.1002/cbic.201600703 Read article
How to get many products from a few instructors: We investigated the RNA-templated transfer reaction between two peptide–PNA conjugates based on native chemical ligation. Thioester reactivity, template architecture, affinity, but not peptide length are key to high-performance peptidyl transfer on RNA.
Margherita Di Pisa, Anett Hauser, Oliver Seitz
ChemBioChem, February 24, 2017, https://doi.org/10.1002/cbic.201600687 Read article
Ultrasound responsive nanodroplets offer advantages over other delivery agents in terms of their ability to penetrate tumor tissue. Successful delivery of siRNA to both lung and breast cancer cell lines is demonstrated with no degradation of the therapeutic. In addition, magnetic targeting of the droplets and correlation between therapeutic effect and the energy of acoustic emissions are shown.
Jeong Yu Lee, Calum Crake, Boon Teo, Dario Carugo, Marie de Saint Victor, Anjali Seth, Eleanor Stride
Adv. Healthcare Mater., February 13, 2017, https://doi.org/10.1002/adhm.201601246 Read article
Mol. Inf., December 21, 2016, https://doi.org/10.1002/minf.201600132 Read article