The Nobel prize in Physiology/Medicine for 2013 was awarded to J. E. Rothman, R. W. Schekman and T C. Südhof for their work on vesicle traffic. Research on vesicles is not only key to our understanding of transport in cells, but also a promising route to drug delivery.
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A programmed liposomal vesicle responsive to the endogenous enzyme, near-infrared light, and temperature is presented. The vesicles can overcome the multiple biological barriers to achieve deep tumor penetration, increased cellular uptake, and intracellular ultrafast drug release. The vesicles coloaded with two chemotherapeutics can be used for combination of photodynamic therapy and chemotherapy of triple negative breast cancer.
Fangyuan Zhou, Bing Feng, Tingting Wang, Dangge Wang, Qingshuo Meng, Jianfeng Zeng, Zhiwen Zhang, Siling Wang, Haijun Yu, Yaping Li
Adv. Funct. Mater., March 24, 2017, https://doi.org/10.1002/adfm.201606530 Read article
Photoconversion-tunable Bodipy polymeric vesicles for wavelength-dependent photoinduced cancer therapy are demonstrated, which mainly generate abundant intracellular singlet oxygen for photodynamic therapy treatment under 660 nm irradiation, while primarily producing potent hyperthermia for photothermal therapy with tumor ablation through singlet oxygen-synergized photothermal necrosis under 785 nm irradiation.
Hui He, Shuangshuang Ji, Yang He, Aijun Zhu, Yelin Zou, Yibin Deng, Hengte Ke, Hong Yang, Youliang Zhao, Zhengqing Guo, Huabing Chen
Adv. Mater., March 15, 2017, https://doi.org/10.1002/adma.201606690 Read article
An aqueous light-harvesting antenna (LHA) is constructed by using hyperbranched polymer vesicles as scaffolds. The donors are encapsulated inside the hydrophobic core layer and the acceptors are incorporated on the shell of vesicles through host–guest interactions. Such a vesicular LHA with spatially separated donors and acceptors can avoid self-quenching effectively and shows good energy transfer efficiency of about 80% in water.
Huimei Li, Yannan Liu, Tong Huang, Meiwei Qi, Yunzhou Ni, Jie Wang, Yongli Zheng, Yongfeng Zhou, Deyue Yan
Macromol. Rapid Commun., February 24, 2017, https://doi.org/10.1002/marc.201600818 Read article
In this paper a combined method of vesicle bilayer templating and hyper-crosslinking to prepare monodisperse microporous polymer nanoparticles with a small size of 61 nm, a high Brunauere–Emmette–Teller surface area up to ≈1300 m2 g−1, and a very high micropore surface area above 1000 m2 g−1 is reported. It also shows the best CO2 uptake property among “Davankov Resins.”
Caiyun Cai, Zhilin Hou, Tong Huang, Ke Li, Yannan Liu, Ning Fu, Sheng Han, Yongfeng Zhou
Macromol. Chem. Phys., February 10, 2017, https://doi.org/10.1002/macp.201700001 Read article
The self-assembly of bolaamphiphilic molecules or bolas is receiving greater attention in recent times owing to their structural diversity and occurrence in natural Archaea species. Compared with the conventional single-headed amphiphiles, bolas have lower critical micelle concentrations and increased water solubility. Deciphering the self-assembly behavior of bolas will have great application potential in wide-ranging areas from material science to biology. This account describes the different types of self-assembled structures and their mechanistic pathways and presents the state of the art concerning sophorolipid (typical abolas and bio-surfactant) self-assembly.
Prabhu Dhasaiyan, Bhagavatula L. V. Prasad
Chem. Rec., November 25, 2016, https://doi.org/10.1002/tcr.201600085 Read article