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Vesicles

The Nobel prize in Physiology/Medicine for 2013 was awarded to J. E. Rothman, R. W. Schekman and T C. Südhof for their work on vesicle traffic. Research on vesicles is not only key to our understanding of transport in cells, but also a promising route to drug delivery.

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Vesicle Origami: Cuboid Phospholipid Vesicles Formed by Template-Free Self-Assembly

Vesicle Origami: Cuboid Phospholipid Vesicles Formed by Template‐Free Self‐Assembly

Cuboid vesicles: A 1,2-diamidophospholipid is presented that self-assembles into the first non-template phospholipid cube. Owing to intermolecular hydrogen bonding, the bilayer membranes form an exceptionally tight subgel packing, leading to a maximization of flat structural elements and a minimization of any edges. These conditions are optimized in the geometrical structure of a cube.

[Communication]
Frederik Neuhaus, Dennis Mueller, Radu Tanasescu, Sandor Balog, Takashi Ishikawa, Gerald Brezesinski, Andreas Zumbuehl
Angew. Chem. Int. Ed., April 26, 2017, https://doi.org/10.1002/anie.201701634 Read article

Glucose-Responsive Supramolecular Vesicles Based on Water-Soluble Pillar[5]arene and Pyridylboronic Acid Derivatives for Controlled Insulin Delivery

Glucose‐Responsive Supramolecular Vesicles Based on Water‐Soluble Pillar[5]arene and Pyridylboronic Acid Derivatives for Controlled Insulin Delivery

Drugs on demand: A glucose-responsive supramolecular drug delivery system based on the host–guest interaction between a water-soluble pillar[5]arene (WP5) and a pyridylboronic acid derivative (G) was constructed for insulin delivery and controlled release under physiological conditions. The approach provides a novel strategy for the construction of glucose-responsive smart supramolecular drug delivery systems and represents the ideal treatment of diabetes mellitus.Wang/Hu et al: Glucose-Responsive Supramolecular Vesicles for Controlled Insulin Delivery

[Full Paper]
Lei Gao, Tingting Wang, Keke Jia, Xuan Wu, Chenhao Yao, Wei Shao, Dongmei Zhang, Xiao-Yu Hu, Leyong Wang
Chem. Eur. J., April 20, 2017, https://doi.org/10.1002/chem.201700345 Read article

Visual Detection of pH and Biomolecular Interactions at Micromolar Concentrations Aided by a Trivalent Diacetylene-Based Vesicle

Visual Detection of pH and Biomolecular Interactions at Micromolar Concentrations Aided by a Trivalent Diacetylene‐Based Vesicle

Aqueous poly(tris-(diacetylene)) vesicle solution obtained from a new tris-(diacetylene) monomer demonstrates reversible chromatism from blue to red in response to external stimuli, that is, temperature and pH. Derivatization of the tris-(diacetylene) monomer with α-d-mannopyranoside moieties and subsequent polymerization of monomeric vesicles in the presence and absence of the lectin display pink and blue color, respectively.

[Full Paper]
Yashapal Singh, Narayanaswamy Jayaraman
Macromol. Chem. Phys., April 18, 2017, https://doi.org/10.1002/macp.201700039 Read article

Deterioration of Aqueous n-Octanoate Electrolysis with Electrolytic Conductivity Collapse Caused by the Formation of n-Octanoic Acid/n-Octanoate Agglomerates

Deterioration of Aqueous n‐Octanoate Electrolysis with Electrolytic Conductivity Collapse Caused by the Formation of n‐Octanoic Acid/n‐Octanoate Agglomerates

Conductivity collapse: Provided that the critical micelle concentration is exceeded, freely moving spherical n-octanoate (C8) micelles agglomerate to vesicles or bilayers for pH≈pKa (see picture) as result of a local pH drop in proximity of the working electrode (WE) during chronoamperometry. This results in poor space−time yields during aqueous electrolysis.

[Article]
Carolin Urban, Falk Harnisch
ChemElectroChem, March 27, 2017, https://doi.org/10.1002/celc.201700069 Read article

Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer

Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple‐Negative Breast Cancer

A programmed liposomal vesicle responsive to the endogenous enzyme, near-infrared light, and temperature is presented. The vesicles can overcome the multiple biological barriers to achieve deep tumor penetration, increased cellular uptake, and intracellular ultrafast drug release. The vesicles coloaded with two chemotherapeutics can be used for combination of photodynamic therapy and chemotherapy of triple negative breast cancer.

[Full Paper]
Fangyuan Zhou, Bing Feng, Tingting Wang, Dangge Wang, Qingshuo Meng, Jianfeng Zeng, Zhiwen Zhang, Siling Wang, Haijun Yu, Yaping Li
Adv. Funct. Mater., March 24, 2017, https://doi.org/10.1002/adfm.201606530 Read article

Construction of Light-Harvesting Polymeric Vesicles in Aqueous Solution with Spatially Separated Donors and Acceptors

Construction of Light‐Harvesting Polymeric Vesicles in Aqueous Solution with Spatially Separated Donors and Acceptors

An aqueous light-harvesting antenna (LHA) is constructed by using hyperbranched polymer vesicles as scaffolds. The donors are encapsulated inside the hydrophobic core layer and the acceptors are incorporated on the shell of vesicles through host–guest interactions. Such a vesicular LHA with spatially separated donors and acceptors can avoid self-quenching effectively and shows good energy transfer efficiency of about 80% in water.

[Communication]
Huimei Li, Yannan Liu, Tong Huang, Meiwei Qi, Yunzhou Ni, Jie Wang, Yongli Zheng, Yongfeng Zhou, Deyue Yan
Macromol. Rapid Commun., February 24, 2017, https://doi.org/10.1002/marc.201600818 Read article

Self-Assembly of Bolaamphiphilic Molecules

Self‐Assembly of Bolaamphiphilic Molecules

The self-assembly of bolaamphiphilic molecules or bolas is receiving greater attention in recent times owing to their structural diversity and occurrence in natural Archaea species. Compared with the conventional single-headed amphiphiles, bolas have lower critical micelle concentrations and increased water solubility. Deciphering the self-assembly behavior of bolas will have great application potential in wide-ranging areas from material science to biology. This account describes the different types of self-assembled structures and their mechanistic pathways and presents the state of the art concerning sophorolipid (typical abolas and bio-surfactant) self-assembly.

[Personal Account]
Prabhu Dhasaiyan, Bhagavatula L. V. Prasad
Chem. Rec., November 25, 2016, https://doi.org/10.1002/tcr.201600085 Read article

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