The Nobel prize in Physiology/Medicine for 2013 was awarded to J. E. Rothman, R. W. Schekman and T C. Südhof for their work on vesicle traffic. Research on vesicles is not only key to our understanding of transport in cells, but also a promising route to drug delivery.
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Inspiration–imitation–innovation: Parallel to the elucidation of the biological properties and physiological function of vesicles, increasingly elegant artificial vesicles are being reported. This Review provides an overview of the complex and rapidly developing fields of natural and synthetic vesicles and shows how the two fields can profit from one another.
Francisco Fernandez-Trillo, Liam M. Grover, Alex Stephenson-Brown, Paul Harrison, Paula M. Mendes
Angew. Chem. Int. Ed., February 16, 2017, DOI: 10.1002/anie.201607825. Read article
Struck by lightning! Electrochemistry is a powerful tool to selectively bleach the fluorescence emitted by redox-active fluorophores localized on the outer leaflet of giant liposomes. This original fluorescence loss in electrobleaching (FLIE) procedure is reliable for exploring the phospholipid reorganization dynamics of a single leaflet in real time. This opens new perspectives to explore important biological and pharmacological issues.
Ana Isabel Perez Jimenez, Lylian Challier, Eric Aït-Yahiatène, Jérôme Delacotte, Eric Labbé, Olivier Buriez
Chem. Eur. J., February 15, 2017, DOI: 10.1002/chem.201605786. Read article
In this paper a combined method of vesicle bilayer templating and hyper-crosslinking to prepare monodisperse microporous polymer nanoparticles with a small size of 61 nm, a high Brunauere–Emmette–Teller surface area up to ≈1300 m2 g−1, and a very high micropore surface area above 1000 m2 g−1 is reported. It also shows the best CO2 uptake property among “Davankov Resins.”
Caiyun Cai, Zhilin Hou, Tong Huang, Ke Li, Yannan Liu, Ning Fu, Sheng Han, Yongfeng Zhou
Macromol. Chem. Phys., February 10, 2017, DOI: 10.1002/macp.201700001. Read article
A series of newly Y-shaped amphiphilic block polyurethane copolymers with two hydrophilic poly(ethylene oxide) (PEO) tails and one hydrophobic alkyl tail is synthesized, which can self-assemble into spherical micelles, small vesicles, and giant unilamellar vesicles by increasing the copolymer concentrations with a direct dissolution method in aqueous solution.
Hanping Li, Yong Jin, Baozhu Fan, Shuangquan Lai, Xiaopeng Sun, Rui Qi
Macromol. Rapid Commun., February 06, 2017, DOI: 10.1002/marc.201600646. Read article
The self-assembly of bolaamphiphilic molecules or bolas is receiving greater attention in recent times owing to their structural diversity and occurrence in natural Archaea species. Compared with the conventional single-headed amphiphiles, bolas have lower critical micelle concentrations and increased water solubility. Deciphering the self-assembly behavior of bolas will have great application potential in wide-ranging areas from material science to biology. This account describes the different types of self-assembled structures and their mechanistic pathways and presents the state of the art concerning sophorolipid (typical abolas and bio-surfactant) self-assembly.
Prabhu Dhasaiyan, Bhagavatula L. V. Prasad
Chem. Rec., November 25, 2016, DOI: 10.1002/tcr.201600085. Read article