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The Nobel prize in Physiology/Medicine for 2013 was awarded to J. E. Rothman, R. W. Schekman and T C. Südhof for their work on vesicle traffic. Research on vesicles is not only key to our understanding of transport in cells, but also a promising route to drug delivery.

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Cell-Engineered Nanovesicle as a Surrogate Inducer of Contact-Dependent Stimuli

Cell‐Engineered Nanovesicle as a Surrogate Inducer of Contact‐Dependent Stimuli

Cell-engineered nanovesicles (CNVs) fabricated from feeder cells successfully regulate the fates of embryonic stem cells through contact-dependent stimulus. Unlike feeder layer methods, scalable, diffusible, and storable characteristics of CNVs can constitute a novel tool for embryonic stem cell research. The CNV method might be used in various other applications that require heterotipic cell–cell interactions.

[Full Paper]
Junho Kim, Chugmin Han, Wonju Jo, Sehong Kang, Siwoo Cho, Dayeong Jeong, Yong Song Gho, Jaesung Park
Adv. Healthcare Mater., June 23, 2017, Read article

Synthesis of BODIPY-Labeled Cholesterylated Glycopeptides by Tandem Click Chemistry for Glycocalyxification of Giant Unilamellar Vesicles (GUVs)

Synthesis of BODIPY‐Labeled Cholesterylated Glycopeptides by Tandem Click Chemistry for Glycocalyxification of Giant Unilamellar Vesicles (GUVs)

Double functionalization of cholesterylated peptide constructs by site-specific tandem click chemistry is described. Copper-free click attachment of a bicyclononyne fluorophore succeeded by copper(I)-catalyzed clicking on an azido-glycan.

Nicolai Stuhr-Hansen, Charikleia-Despoina Vagianou, Ola Blixt
Chem. Eur. J., June 22, 2017, Read article

Efficient Fusion of Liposomes by Nucleobase Quadruple-Anchored DNA

Efficient Fusion of Liposomes by Nucleobase Quadruple‐Anchored DNA

A powerful new approach is reported to achieve vesicle–vesicle fusion by employing DNA with four lipid-modified bases at the terminus to tightly anchor the nucleotide to the bilayer of vesicles. This strategy achieved a highly stable incorporation of DNA into the liposomal bilayer, thereby limiting dissociation and keeping the base-pairing nucleotides close to the surface and allowing for a markedly more efficient full fusion as compared to other, previously reported, anchoring strategies.

[Full Paper]
Zhuojun Meng, Jian Yang, Qing Liu, Jan Willem de Vries, Agnieszka Gruszka, Alberto Rodríguez-Pulido, Bart J. Crielaard, Alexander Kros, Andreas Herrmann
Chem. Eur. J., June 20, 2017, Read article

Construction of Light-Harvesting Polymeric Vesicles in Aqueous Solution with Spatially Separated Donors and Acceptors

Construction of Light‐Harvesting Polymeric Vesicles in Aqueous Solution with Spatially Separated Donors and Acceptors

An aqueous light-harvesting antenna (LHA) is constructed by using hyperbranched polymer vesicles as scaffolds. The donors are encapsulated inside the hydrophobic core layer and the acceptors are incorporated on the shell of vesicles through host–guest interactions. Such a vesicular LHA with spatially separated donors and acceptors can avoid self-quenching effectively and shows good energy transfer efficiency of about 80% in water.

Huimei Li, Yannan Liu, Tong Huang, Meiwei Qi, Yunzhou Ni, Jie Wang, Yongli Zheng, Yongfeng Zhou, Deyue Yan
Macromol. Rapid Commun., February 24, 2017, Read article

Self-Assembly of Bolaamphiphilic Molecules

Self‐Assembly of Bolaamphiphilic Molecules

The self-assembly of bolaamphiphilic molecules or bolas is receiving greater attention in recent times owing to their structural diversity and occurrence in natural Archaea species. Compared with the conventional single-headed amphiphiles, bolas have lower critical micelle concentrations and increased water solubility. Deciphering the self-assembly behavior of bolas will have great application potential in wide-ranging areas from material science to biology. This account describes the different types of self-assembled structures and their mechanistic pathways and presents the state of the art concerning sophorolipid (typical abolas and bio-surfactant) self-assembly.

[Personal Account]
Prabhu Dhasaiyan, Bhagavatula L. V. Prasad
Chem. Rec., November 25, 2016, Read article

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