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Vesicles

The Nobel prize in Physiology/Medicine for 2013 was awarded to J. E. Rothman, R. W. Schekman and T C. Südhof for their work on vesicle traffic. Research on vesicles is not only key to our understanding of transport in cells, but also a promising route to drug delivery.

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Autonomous Ex Novo Chemical Assembly with Blebbing and Division of Functional Polymer Vesicles from a “Homogeneous Mixture”

Autonomous Ex Novo Chemical Assembly with Blebbing and Division of Functional Polymer Vesicles from a “Homogeneous Mixture”

This study discusses the synthesis of amphiphilic block copolymers that self-assemble into micrometer-sized vesicles, while simultaneously entrapping the reaction that provides the radicals needed for the polymerization and shows their blebbing, a first step to system division, due to an internal reaction. The system does not use any biochemistry.

[Communication]
Bishnu Prasad Bastakoti, Juan Perez-Mercader
Adv. Mater., October 06, 2017, https://doi.org/10.1002/adma.201704368 Read article

Theranostic Prodrug Vesicles for Reactive Oxygen Species-Triggered Ultrafast Drug Release and Local-Regional Therapy of Metastatic Triple-Negative Breast Cancer

Theranostic Prodrug Vesicles for Reactive Oxygen Species‐Triggered Ultrafast Drug Release and Local‐Regional Therapy of Metastatic Triple‐Negative Breast Cancer

A reactive oxygen species (ROS)-activatable doxorubicin prodrug vesicle (RADV) is reported for image-guided local-regional therapy of triple-negative breast cancer (TNBC). Under the guidance of fluorescence and photoacoustic imaging, NIR laser irradiation is performed to induce ROS generation and trigger drug release at the tumor site. RADV efficiently inhibits TNBC tumor growth and distant metastasis by combing photodynamic and locally activated chemotherapy.

[Full Paper]
Fangyuan Zhou, Bing Feng, Tingting Wang, Dangge Wang, Zhirui Cui, Siling Wang, Chunyong Ding, Zhiwen Zhang, Jian Liu, Haijun Yu, Yaping Li
Adv. Funct. Mater., October 04, 2017, https://doi.org/10.1002/adfm.201703674 Read article

Gb3 Glycosphingolipids with Fluorescent Oligoene Fatty Acids: Synthesis and Phase Behavior in Model Membranes

Gb3 Glycosphingolipids with Fluorescent Oligoene Fatty Acids: Synthesis and Phase Behavior in Model Membranes

Get in place! Fluorescent labels can alter the phase behavior of lipids considerably. The synthetic route to fatty acid-labeled Gb3 derivatives that partition in the liquid-disordered phase, even after binding of Shiga toxin B subunits, is described.

[Full Paper]
Lukas J. Patalag, Jeremias Sibold, Ole M. Schütte, Claudia Steinem, Daniel B. Werz
ChemBioChem, September 20, 2017, https://doi.org/10.1002/cbic.201700414 Read article

Controlling Complex Stability in Photoresponsive Macromolecular Host–Guest Systems: Toward Reversible Capture of DNA by Cyclodextrin Vesicles

Controlling Complex Stability in Photoresponsive Macromolecular Host–Guest Systems: Toward Reversible Capture of DNA by Cyclodextrin Vesicles

The light-responsive capture and release of high molecular weight DNA is achieved using two different strategies, balancing complex stability and stimuli-responsive release. The first approach employs a competitive stopper for controlling the binding of the biopolymer in the photostationary state. Alternatively, arylazopyrazole is used as a superior light-responsive moiety to achieve control over charge density and complexation.

[Communication]
Johanna Moratz, Lucas Stricker, Sabrina Engel, Bart Jan Ravoo
Macromol. Rapid Commun., September 12, 2017, https://doi.org/10.1002/marc.201700256 Read article

“Breathing” CO2-, O2-, and Light-Responsive Vesicles from a Triblock Copolymer for Rate-Tunable Controlled Release

“Breathing” CO2‐, O2‐, and Light‐Responsive Vesicles from a Triblock Copolymer for Rate‐Tunable Controlled Release

“Breathing” vesicles are self-assembled from a CO2-, O2-, and light-responsive amphiphilic block copolymer in aqueous solution. The size of these vesicles could be reversibly adjusted via addition and removal of external stimuli to present corresponding “breathing” transition behaviors. Based on this feature, these vesicles can exhibit rate-tunable controlled release behavior depending on external stimuli.

[Communication]
Shaojian Lin, Jiaojiao Shang, Xiaoxiao Zhang, Patrick Theato
Macromol. Rapid Commun., August 09, 2017, https://doi.org/10.1002/marc.201700313 Read article

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