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Vesicles

The Nobel prize in Physiology/Medicine for 2013 was awarded to J. E. Rothman, R. W. Schekman and T C. Südhof for their work on vesicle traffic. Research on vesicles is not only key to our understanding of transport in cells, but also a promising route to drug delivery.

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“Breathing” CO2-, O2-, and Light-Responsive Vesicles from a Triblock Copolymer for Rate-Tunable Controlled Release

“Breathing” CO2‐, O2‐, and Light‐Responsive Vesicles from a Triblock Copolymer for Rate‐Tunable Controlled Release

“Breathing” vesicles are self-assembled from a CO2-, O2-, and light-responsive amphiphilic block copolymer in aqueous solution. The size of these vesicles could be reversibly adjusted via addition and removal of external stimuli to present corresponding “breathing” transition behaviors. Based on this feature, these vesicles can exhibit rate-tunable controlled release behavior depending on external stimuli.

[Communication]
Shaojian Lin, Jiaojiao Shang, Xiaoxiao Zhang, Patrick Theato
Macromol. Rapid Commun., August 09, 2017, https://doi.org/10.1002/marc.201700313 Read article

Engineering Globular Protein Vesicles through Tunable Self-Assembly of Recombinant Fusion Proteins

Engineering Globular Protein Vesicles through Tunable Self‐Assembly of Recombinant Fusion Proteins

Globular protein vesicles are self-assembled from globule-zipper-elastin-like polypeptide (ELP) protein complexes upon warming. The vesicle self-assembly proceeds according to the packing parameter of the fusion protein complexes, which depends on the ELP domain phase. The size and membrane structure of the globular protein vesicles are engineered by tuning the molecular packing parameter via protein concentration or temperature.

[Full Paper]
Yeongseon Jang, Won Tae Choi, William T. Heller, Zunlong Ke, Elizabeth R. Wright, Julie A. Champion
Small, July 27, 2017, https://doi.org/10.1002/smll.201700399 Read article

Cell-Engineered Nanovesicle as a Surrogate Inducer of Contact-Dependent Stimuli

Cell‐Engineered Nanovesicle as a Surrogate Inducer of Contact‐Dependent Stimuli

Cell-engineered nanovesicles (CNVs) fabricated from feeder cells successfully regulate the fates of embryonic stem cells through contact-dependent stimulus. Unlike feeder layer methods, scalable, diffusible, and storable characteristics of CNVs can constitute a novel tool for embryonic stem cell research. The CNV method might be used in various other applications that require heterotipic cell–cell interactions.

[Full Paper]
Junho Kim, Chugmin Han, Wonju Jo, Sehong Kang, Siwoo Cho, Dayeong Jeong, Yong Song Gho, Jaesung Park
Adv. Healthcare Mater., June 23, 2017, https://doi.org/10.1002/adhm.201700381 Read article

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