Visible-light Driven Hydrolysis of Benzyl Halides with Water for Preparation of Benzyl Alcohols

A mild, simple, and clean method has been reported for the hydrolysis of various benzyl halides under visible-light driven system using rhodamine B as the photocatalyst, which was found to be an efficient photosensitizer for this reaction. Benzyl bromides and benzyl chlorides could smoothly react with water to give the alcohols in good yields.

[Communication]
Dr. Jianbin Xu, Na Liu, Lingling Zou, Prof. Feixiang Cheng, Dr. Xianfu Shen, Dr. Teng Liu, Haiping Lv, Dr. Ruhima Khan, Prof. Dr. Baomin Fan
doi.org/10.1002/ajoc.201800658

Scandium(III)-Catalysed Decarboxylative Addition of β-Ketoacids to para-Quinone Methides: Evidence for 1,6-Addition and Base-Assisted Decarboxylation Tandem Process

A catalytic tandem 1,6-addition/decarboxylation process of β-ketoacids and para-quinone methides under scandium triflate catalysis and subsequent triethylamine treatment has been developed. The 1H NMR and ESI-HRMS experiments displayed direct evidences for the reaction pathway.

[Communication]
Dr. Chunhui Jiang, Yayun Chen, Gaokui Huang, Cheng Ni, Dr. Xiaoqian Liu, Dr. Hongfei Lu
doi.org/10.1002/ajoc.201800729

Rational Design and Synthesis of Reversible Covalent PPARγ Antagonistic Ligands Inhibiting Ser273 Phosphorylation

The other way around: A revesible covalent peroxisome proliferator-activated receptor gamma (PPARγ) inhibitor of Ser273 phosphorylation was developed by introducing a reversible covalent cyanoacrylamide moiety. Through systematic structure modification and in silico simulations, a series of reversible covalent inhibitors with improved aqueous stability were designed and synthesized. Biological studies revealed that SB1495 inhibits the phosphorylation of PPARγ without unwanted classical transcriptional agonism.

[Full Paper]
Hyunsoo Kim, Ala Jo, Dr. Sun-Sil Choi, Hyunsung Nam, Wan Gi Byun, Hwan Bae, Prof. Dr. Jang Hyun Choi, Prof. Dr. Seung Bum Park
doi.org/10.1002/ajoc.201800668

Air-Stable Symmetric Ambipolar Field-Effect Transistors Based on Reduced Graphene Oxide-OTS Self-Assembled Monolayer Heterostructure

Monolayer of octadecyltrichlorosilane (OTS) is successfully self-assembled on the surface of reduced graphene oxide (RGO), and RGO-OTS SAM heterostructure is fabricated for FET devices, which exhibits air stable intrinsic symmetric ambipolar field-effect behavior with the Dirac point at the 0 V gate voltage and negligible hysteresis.

[Full Paper]
Peng Peng, Dr. Hongtao Liu, Prof. Bin Wu, Prof. Qingxin Tang, Prof. Yunqi Liu
doi.org/10.1002/cnma.201800567

Halide-Induced Leaching of Pt Nanoparticles - Manipulation of Particle Size by Controlled Ostwald Ripening

Colloidal “surfactant-free” Pt NPs were used to study the stability of NP dispersions. It was found that leaching and subsequent Ostwald ripening occurs in the presence of halides and oxygen. The gained knowledge was used to control the size of “surfactant-free” Pt NP within a range of 1-4 nm.

[Full Paper]
Sarah Neumann, Johanna Schr�der, Francesco Bizzotto, Matthias Arenz, Alexandra Dworzak, Mehtap Oezaslan, Marcus B�umer, Dr. Sebastian Kunz
doi.org/10.1002/cnma.201800550