An Allosteric Metal-Organic Framework That Exhibits Multiple Pore Configurations for the Optimization of Hydrocarbon Separation

Something to pore over: Multiple pore configurations have been realized in an ionic metal-organic framework through the dynamic transformation upon various solvation/desolvation routes, in which the allocation and orientation of the counter ions in the pore act as an allosteric site in the channel for tuning the hydrocarbon separation performance (see figure).

[Communications]
Beibei Zhou, Tengwu Zeng, Zhao-Lin Shi, Dr. Gen Zhang, Prof. Dr. Satoshi Horike, Prof. Dr. Yue-Biao Zhang
doi.org/10.1002/asia.201900239

Surface Charge-Reversible Tubular Micromotors for Extraction of Nucleic Acids in Microsystems

A good catch: A simple, versatile and efficient approach to extract nucleic acids in microsystems was demonstrated by developing cationic branched polyethyleneimine (PEI)-functionalized tubular micromotors. The PEI-functionalized tubular micromotor can selectively capture nucleic acids from an acid medium and recover the captured nucleic acids in a basic medium.

[Full Papers]
Dr. Ming Luo, Yuzhou Jiang, Jingbei Su, Zhuoyi Deng, Dr. Fangzhi Mou, Dr. Leilei Xu, Prof. Jianguo Guan
doi.org/10.1002/asia.201900427

Peptide-Modified Mo Polyoxometalate Nanoparticles Suppress Zn2+-Induced Aβ Aggregation

Peptide@POMs nanoparticles with Aβ-targeting peptides are used for Alzheimer's disease treatment in mice. First, synthetic peptide-modified Mo-POM nanoparticles are synthesized. Then, the assembled Peptide@POMs nanoparticles can effectively inhibit Zn2+-induced Aβ40 aggregation, penetrate the blood-brain barrier, and bind to Aβ. In addition, Peptide@POMs nanoparticles protect neurons from Aβ40-mediated neurotoxicity.

[Full Papers]
Dr. Yanan Liu, Jing Sun, Youcong Gong, Hui Zhou, Xu Chen, Xufeng Zhu, Yingyu Zhao, Yayu Wen, Xiuying Qin, Prof. Dr. Jie Liu
doi.org/10.1002/cnma.201900057