Methane monooxygenase: The chaperonin GroES/EL enables folding and correct assembly of soluble methane monooxygenase (sMMO) heterologously produced in Escherichia coli. The production of recombinant sMMO will enable a variety of novel biotechnological applications in future.
[Research Articles]
Domenic Zill, Elisabeth Lettau, Christian Lorent, Dr. Franziska Seifert, Dr. Praveen K. Singh, Prof. Dr. Lars Lauterbach
doi.org/10.1002/cbic.202200195
Cubane aptamer (cubamer) is a chemically modified nucleic acid aptamer incorporating cubane moieties into the nucleotide bases. The Figure shows a cubamer in complex with the malaria biomarker Plasmodium vivax lactate dehydrogenase (PvLDH), with high specificity relative to Plasmodium falciparum lactate dehydrogenase (PfLDH). Such specificity has not been possible with conventional DNA aptamers. This example demonstrates the enhanced functionality of modified aptamers. Herein, we review the chemistry, synthesis, selection, and application of such modified aptamers.
[Reviews]
Kwing Yeung Chan, Andrew Brian Kinghorn, Marcel Hollenstein, Julian Alexander Tanner
doi.org/10.1002/cbic.202200006
A structured 3D-printed microreactor coated with a single-atom catalytic layer is presented and evaluated for continuous-flow hydrogenations. The work paves the way for the practical and industrial-scale utilization of single-atom catalysts in structured form.
[Research Articles]
Prof. Gianvito Vil�, Dr. Derrick Ng, Dr. Zongli Xie, Ivan Martinez-Botella, Dr. John Tsanaktsidis, Dr. Christian H. Hornung
doi.org/10.1002/cctc.202101941
Fe species: Highly dispersed monomeric and dimeric Fe species on H-MOR can efficiently homogenize H2O2 to active hydroxyl groups for mild methane partial oxidation, while Fe clusters decompose H2O2 into inactive O2.
[Research Articles]
Zhihao Fang, Mengyuan Huang, Dr. Bing Liu, Jie Chen, Dr. Feng Jiang, Dr. Yuebing Xu, Prof. Xiaohao Liu
doi.org/10.1002/cctc.202200218
Li−Ca binary salt hydrate: Significant improvement in the cycle performance of a Li4Ti5O12 electrode was achieved using a Li−Ca binary salt hydrate (LCH) electrolyte in combination with an optimized electrochemical pretreatment process. The LCH electrolyte provided less water-soluble Ca-based SEI components, and careful pretreatment process enabled the formation of a thicker SEI layer on the Li4Ti5O12 electrode, leading to 95.5 % capacity retention over 50 cycles.
[Research Articles]
Shinji Kondou, Yoshifumi Watanabe, Prof. Kaoru Dokko, Prof. Masayoshi Watanabe, Prof. Kazuhide Ueno
doi.org/10.1002/celc.202200061
New strategies for spatially organizing multienzyme biocatalytic cascades using porous organic frameworks are discussed in this Concept article, describing how this new bio-nanosystem that integrates framework and enzyme functions can be designed as a versatile biosensing platform.
[Concepts]
Rui Gao, Ningyi Zhong, Prof. Siming Huang, Shuocong Li, Prof. Guosheng Chen, Prof. Gangfeng Ouyang
doi.org/10.1002/chem.202200074
Radical hydrazinium: A highly labile hydrazinium-yl radical cation, [(Me3Si)2N−N(H)SiMe3].+, formed by a one-electron oxidation of tris(trimethylsilyl) hydrazine, (Me3Si)2N−N(H)SiMe3, with silver salts is presented. The structural and electronic parameters of the hydrazinium-yl radical cation were elucidated, revealing that the spin density in the isolated radical is mainly localized along the N−N unit of the hydrazine moiety.
[Research Articles]
Dr. Fabian Reiß, Dr. Alexander Villinger, Dr. Harald Brand, Dr. Wolfgang Baumann, Dr. Dirk Hollmann, Prof. Dr. Axel Schulz
doi.org/10.1002/chem.202200854
The Brønsted basic properties of diphenylberyllium have been used to cleanly produce a range of important benchmark compounds. The long-suspected structure of [Be3(OtBu)6] is finally verified, and shown to be static in solution; the NHC-stabilised beryllium Grignard is the first of its kind. The stark differences between Be−N and Be−P interactions are also evidenced here.
[Research Articles]
Dr. Lewis R. Thomas-Hargreaves, Chantsalmaa Berthold, William Augustinov, Dr. Matthias M�ller, Dr. Sergei I. Ivlev, Dr. Magnus R. Buchner
doi.org/10.1002/chem.202200851
A new type of biocompatible phosphate analog, the fluorophosphoramidate (FPA) functional group, was developed. With the appropriate molecular design, the FPA group can be converted into the corresponding phosphate group in cells and is thus applicable as a phosphate prodrug for nucleoside analogs. One of the several FPA-gemcitabine prodrugs showed effectively high toxicity toward pancreatic cancer cells, demonstrating the effectiveness of FPA-based prodrugs.
[Research Articles]
Yuki Yoshida, Ti Zheng, Wataru Tanabe, Dr. Fumiaki Tomoike, Dr. Fumitaka Hashiya, Prof. Dr. Tetsuro Suzuki, Shuto Hirota, Dr. Yuriko Saiki, Prof. Dr. Akira Horii, Dr. Akiyoshi Hirayama, Prof. Dr. Tomoyosi Soga, Dr. Yasuaki Kimura, Prof. Dr. Hiroshi Abe
doi.org/10.1002/cmdc.202200188
The single-crystal-to-single-crystal photodimerization of the bromide salt of the 4-aminocinnamic acid, taken as a model system for this class of reactions, is demonstrated to display a clear spectral signature in a low-wavenumber Raman investigation assisted by dispersion-corrected DFT simulations.
[Research Articles]
Dr. Andrea Giunchi, Lorenzo Pandolfi, Dr. Tommaso Salzillo, Prof. Aldo Brillante, Prof. Raffaele G. Della Valle, Dr. Simone d'Agostino, Prof. Elisabetta Venuti
doi.org/10.1002/cphc.202200168
Incorporation of N-atoms into the inner rings of large polycyclic aromatic hydrocarbons (PAHs) results in significant planarity deviation and molecular dipole moment change. On the other hand, the induced current densities and aromatic character remain practically unchanged relative to the corresponding undoped PAH molecules.
[Research Articles]
Dr. Slavko Radenković, Prof. Dr. Željko Tomović
doi.org/10.1002/cphc.202200125
Two in one: The complex process of simultaneous cobalt deposition and hydrogen evolution is described using a two-plate mathematical model (I plate is the GCE, II plate is the deposited cobalt layer). The kinetic parameters are determined from the experimental curves. The qualitative and quantitative fit of the model to the experimental data is investigated.
[Research Articles]
Dr. Piotr M. Skitał, Aleksandra J. Domańska
doi.org/10.1002/cphc.202200148
Carbon Quantum Dots (CQDs) offer a variety of features and can act as an efficient semiconductor photocatalyst for the treatment of several environmental pollutants. This review summarizes various CQDs and their hybrid-based photocatalysts that can be potentially used to remove water pollutants with the help of visible light.
[Reviews]
Athulya M., Bony K. John, Anu Rose Chacko, Chitra Mohan, Dr. Beena Mathew
doi.org/10.1002/cphc.202100873
No limits: Electrocatalytic nitrogen reduction to ammonia is catalyzed by WX2 (X=S, Se, Te) monolayers in the 1T′ phase with antisite defects exhibiting low limiting potentials (≈0.2 V), while the competing hydrogen evolution reaction is inhibited.
[Research Articles]
Mamutjan Tursun, Prof. Chao Wu
doi.org/10.1002/cssc.202200191
If life gives you melem… Melem is used instead of g-C3N4 to construct an all-organic heterojunction with pyromellitic dianhydride. The photocatalytic NO removal activity of the all-organic heterojunction constructed with melem is considerably higher than that constructed with g-C3N4. This is because melem has more −NH2 to form more heterojunction knots, which enable the effective transfer and separation of electron-hole pairs.
[Research Articles]
Yuxin Li, Zeyu Jiang, Prof. Guohui Dong, Prof. Wingkei Ho
doi.org/10.1002/cssc.202200477
Sensing with COFs: A series of covalent organic frameworks (COFs), [OMe]x−TzDa (X=2, 1, 0.5), are synthesized and their photochemical behaviors change significantly with the variation in doping ratios of OMe and OH. [OMe]2−TzDa, with a ratio of 2/1 of OMe/OH, showed the strongest fluorescence emission in water, resulting in its excellent fluorescence response to pH and N2H4 as well as colorimetric sensing of HCl and NH3 gases.
[Research Articles]
Jilu Yang, Yuping Cao, Wenbo Si, Jin Zhang, Jiemin Wang, Yi Qu, Prof. Dr. Wenwu Qin
doi.org/10.1002/cssc.202200100
Renewable thermoset: Kraft lignin, a by-product from the paper and pulp industry is mixed with a cross-linking mixture based on adipic acid able to react with lignin under heat. The resulting material is a partially esterified mixture with thermoplastic-like properties. Such a liquid can undergo further thermal treatment inside a mold under pressure to yield a tunable thermoset without any additives.
[Research Articles]
Dr. Davide Di Francesco, Dr. Davide Rigo, Dr. Kiran Reddy Baddigam, Prof. Aji P. Mathew, Prof. Niklas Hedin, Prof. Maurizio Selva, Prof. Joseph S. M. Samec
doi.org/10.1002/cssc.202200326
Geminal Bisphosphonate (BP) Esters in Ca(II) Ion Coordination. A series of geminal BPs was prepared starting from their corresponding ethyl- or isopropyl (arylmethylene)phosphonate ester precursors. Complexation with CaCl2 yields the derived coordination compounds [Ca(H2O)2(L1-L3)2]Cl2 or [Ca(L8)Cl2]n. Their structures in the solid- (SCXRD) as well as solution-state (1H DOSY NMR) are evaluated and comprehensively compared to literature data.
[Research Articles]
Dr. Ingo Koehne, Prof. Dr. Rudolf Pietschnig
doi.org/10.1002/ejic.202200194
Herein, palladium(II)-catalyzed halogenation of 2-phenylquinazolines using N-halosuccinimides as halogen sources was described via C−H activation under mild reaction conditions. A series of halogen-substituted 2-arylquinazolines were synthesized through C−H functionalization.
[Research Articles]
Yong Wang, Hui Wang, Qifan Yang, Shihua Xie, Prof. Hongjun Zhu
doi.org/10.1002/ejoc.202200316
This Review summarizes recent advances in optical molecular probes used to detect cyanide ions based on five representative families of probes containing triphenylamine, BODIPY, coumarin, pyrene, and pyrazolo[1,5-a]pyrimidine. In particular, the analysis focuses on the sustainable synthesis of compounds considering some environmental and economic factors.
[Reviews]
Dr. Alexis Tigreros, Prof. Dr. Jaime Portilla
doi.org/10.1002/ejoc.202200249
A guide to the chemist's toolbox for the stimulation of invariant natural killer (iNKT) cells. This Review encompasses the synthetic strategies for the preparation of the iNKT cell agonist α-galactosylceramide (αGalCer), its TH1/TH2 skewing analogs, and other synthetic probes for the elucidation of mechanisms of αGalCer trafficking.
[Reviews]
Dr. Cecilia Romanò, Prof. Mads H. Clausen
doi.org/10.1002/ejoc.202200246