Bioluminescence Profiling of NanoKAZ/NanoLuc Luciferase Using a Chemical Library of Coelenterazine Analogues

It's the organic chemistry! From an original marine luciferin synthetic pathway, an extensive structure-bioluminescence relationship study led to original and enhanced substrates of the extensively mutated luciferase nanoKAZ/NanoLuc originating from the deep sea shrimp Oplophorus gracilirostris.

[Full Papers]
Dr. Eloi P. Coutant, Dr. Glwadys Gagnot, Vincent Hervin, Racha Baatallah, Prof. Dr. Sophie Goyard, Dr. Yves Jacob, Dr. Thierry Rose, Prof. Dr. Yves L. Janin

Hetero Diels-Alder Reactions of Masked Dienes Containing Heavy Group 15 Elements

Brilliant disguise: The unprecedented behavior of N,C,N-chelated organopnictogen(I) compounds ArE (E=As, Sb, Bi), capable of reacting as masked dienes in hetero Diels-Alder reactions, thus producing unique heterocycles, is reported.

[Full Papers]
Ing. Monika Kořenková, Ing. Vít Kremláček, Dr. Martin Hejda, Dr. Jan Turek, Dr. Raffi Khudaverdyan, Prof. Milan Erben, Prof. Roman Jambor, Prof. Aleš Růžička, Prof. Libor Dostál

Metal-Organic Sheets for Efficient Drug Delivery and Bioimaging

We developed a nanoscale MOF sheet (NZIF−L) as a novel nanocarrier. DOX and TCPE were loaded respectively. After cellular uptake, the fabricated DOX@NZIF−L and TCPE@NZIF−L could be used for anti-tumor and imaging respectively. DOX@NZIF−L showed excellent cytotoxicity and fluorescent imaging effect against HeLa cells. The study of endocytosis behavior of RAW264.7 cells further proved the NZIF−L a good nanocarrier for drug delivery and bioimaging.

Yucong Song, Jingjie Yang, Dr. Lei Wang, Prof. Zhigang Xie

Kemp Elimination Reaction Catalyzed by Electric Fields

Fields for enzymes: The effect of two different kinds of electric fields, the solvent reaction field and oriented external fields, in the Kemp elimination reaction (see the Figure) has been theoretically studied. We have shown that both kinds of electric fields may have a catalytic effect on the Kemp reaction and that this can provide a new strategy for improving the de novo design of new enzymes.

Dr. Carles Acosta-Silva, Prof. Joan Bertran, Prof. Vicen� Branchadell, Prof. Antoni Oliva

Framework Effects on Activation and Functionalisation of Methane in Zinc-Exchanged Zeolites

It's all about the framework! The zeolite framework is shown to influence the number of extraframework zinc species that can activate methane as well as the observed oxidation products. Selective methanol formation is demonstrated utilising the MOR framework.

Meera A. Shah, Samuel Raynes, Dr. David C. Apperley, Dr. Russell A. Taylor

Hollow Nano-Mesosilica Spheres Containing Rhodium Nanoparticles Supported on Nitrogen-Doped Carbon: An Efficient Catalyst for the Reduction of Nitroarenes under Mild Conditions

Fully loaded: Rhodium nanoparticles supported on nitrogen-doped carbon within hollow mesoporous silica spheres act as nanoreactors. They exhibit excellent conversion and selectivity in hydrogenation reduction of nitroaromatic species under mild conditions. The catalyst structure prevents aggregation and leaching of Rh NPs during the reaction, so that stability can be obtained over multiple cycles.

[Full Papers]
Shihan Wang, Jinyu Dai, Zhiqiang Shi, Zeshan Xiong, Prof. Zongtao Zhang, Prof. Shilun Qiu, Prof. Runwei Wang

Room Temperature Phosphorescent (RTP) N-Acetylphenothiazines

A bit of this, a bit of that: Room-temperature phosphorescence was achieved from simple molecules, specifically N-acetylphenothiazines, with a donor-acceptor architecture.

Tanmay Kumar Sarkar, Samir Kumar Sarkar, Prof. Pakkirisamy Thilagar

Precursor-Engineering Coupled Microwave Molten-Salt Strategy Enhances Photocatalytic Hydrogen Evolution Performance of g-C3N4 Nanostructures

Precursors and blessings: A precursor-engineering strategy coupled with a microwave molten-salt process is developed to synthesize g-C3N4 with an isotype triazine/heptazine-based g-C3N4 heterojunction as a photocatalyst for the hydrogen evolution reaction (HER) under visible light illumination. The promising HER activity is attributed to the composition and microstructure, efficient separation of electron-hole pairs, broadened photo-absorption edges, and narrowed band gaps.

[Full Papers]
Huijuan Jing, Mingzhu You, Shasha Yi, Tao Li, Haipeng Ji, Yu Wang, Zongtao Zhang, Prof. Rui Zhang, Prof. Deliang Chen, Prof. Huaming Yang

Domino Hydroalkoxylation-[4+2]-Cycloaddition for Stereoselective Synthesis of 1,4-Heterocycle-Fused Chromenes: Rapid Access to the [6-6-7-6] Tetracyclic Core of Cytorhizhins B-D

A substrate dependent regio- and stereoselective domino hydroalkoxylation-formal cycloaddition is described for the facile synthesis of linear as well as spirocyclic 1,4-heterocycle-fused chromenes. The developed hydroalkoxylation cascade offered a quick access to the [6-6-7-6] tetracyclic framework of cytorhizhins B-D.

Santosh J. Gharpure, Santosh K. Nanda, Dipak J. Fartade, Dharmendra S. Vishwakarma

Three Step Synthesis of Fully and Differently Arylated Pyridines

Condensation of β-(2-pyridyl)enamine and α,β-unsaturated ketone in the presence of FeCl3 under air afforded highly substituted pyridines. Synthesis of differently substituted pentaarylpyridines was consequently achieved via only three steps from commercially available reagents with simple experimental manipulations.

[Full Papers]
Mao Arita, Soichi Yokoyama, Haruyasu Asahara, Nagatoshi Nishiwaki

Chemoenzymatic Synthesis of Sertraline

A chemoenzymatic approach has been developed for the preparation of sertraline. Ketoreductases (KREDs) were employed to yield a key chiral precursor. The bioreduction of the racemic tetralone exhibited excellent enantioselectivity (>99 % ee) and diastereomeric ratio (99:1) at 29 % conversion.

[Full Papers]
Lisa Marx, Nicol�s R�os-Lombard�a, Philipp S�ss, Matthias H�hne, Francisco Mor�s, Javier Gonz�lez-Sab�n, Per Berglund

Nitrene Transfer Reactions for Asymmetric C-H Amination: Recent Development

Transition-metal-catalyzed C-H bond amination through nitrene transfer is a straightforward method to provide chiral aminated compounds. This minireview focuses on recent strategies for the asymmetric C-H amination towards enantioenriched products with several nitrogen sources cataylzed by small molecule complexes or artificial metalloenzymes.

Hiroki Hayashi, Tatsuya Uchida