Stereo- and Regioselective Construction of Spirooxindoles Having Continuous Spiral Rings via Asymmetric [3+2] Cyclization of 3-Isothiocyanato Oxindoles with Thioaurone Derivatives

Stereo- and Regioselective Construction of Spirooxindoles Having Continuous Spiral Rings via Asymmetric [3+2] Cyclization of 3-Isothiocyanato Oxindoles with Thioaurone Derivatives

A highly efficient enantioselective [3+2] cyclization of 3-isothiocyanato oxindoles with thioaurone derivatives was developed for the synthesis of spirooxindoles containing continuous spiral ring structures.

[Full Papers]
Dr. Hou-Ze Gui, Zhe Meng, Zhan-Shuai Xiao, Ze-Ren Yang, Prof. Dr. Yin Wei, Prof. Dr. Min Shi
European Journal of Organic Chemistry, https://doi.org/10.1002/ejoc.202001146. Read article.

Diazanorbornene: A Valuable Synthon towards Carbocycles and Heterocycles

Diazanorbornene: A Valuable Synthon towards Carbocycles and Heterocycles

The present review summarizes the recent progress on desymmetrization of diazanorbornenes towards substituted/fused cyclopentanoids through catalyzed or uncatalyzed pathways.

[Review]
Dr. Preethanuj Preethalayam, Dr. E. Jijy, Dr. Praveen Prakash, Dr. Sarath Chand Sarngadharan, Dr. Ajesh Vijayan, Dr. K. V. Radhakrishnan, Dr. Jubi John
European Journal of Organic Chemistry, https://doi.org/10.1002/ejoc.202001131. Read article.

Recent Developments in Metalloporphyrin Electrocatalysts for Reduction of Small Molecules: Strategies for Managing Electron and Proton Transfer Reactions

Recent Developments in Metalloporphyrin Electrocatalysts for Reduction of Small Molecules: Strategies for Managing Electron and Proton Transfer Reactions

Adding hydrogen at no charge: Recent advances in metalloporphyrin catalysts transformation of O2 and CO2 are reviewed. Emphasis is placed on homogeneous and heterogeneous catalysts that feature designs to account for both proton and electron transfer reactions. The importance of proton transfer in determining product selectivity is described, and reaction developments in understanding mechanisms are summarized.

[Minireviews]
Rui Zhang, Prof. Jeffrey J. Warren
ChemSusChem, https://doi.org/10.1002/cssc.202001914. Read article.

Single-Atom and Dual-Atom Electrocatalysts Derived from Metal Organic Frameworks: Current Progress and Perspectives

Single-Atom and Dual-Atom Electrocatalysts Derived from Metal Organic Frameworks: Current Progress and Perspectives

MOFs all around! Recent progress of metal-organic frameworks (MOFs)-derived single- and dual-atom catalysts for oxygen reduction reaction, oxygen evolution reaction, hydrogen evolution reaction, carbon dioxide reduction reaction, and nitrogen reduction reaction are reviewed to provide a deep understanding of MOFs-based atomic electrocatalysts, and to promote further design and applications of atomic electrocatalysts.

[Reviews]
Dr. Siru Chen, Ming Cui, Zehao Yin, Dr. Jiabin Xiong, Prof. Liwei Mi, Dr. Yanqiang Li
ChemSusChem, https://doi.org/10.1002/cssc.202002098. Read article.

Biodegradable Plastics: Standards, Policies, and Impacts

Biodegradable Plastics: Standards, Policies, and Impacts

Waste not! This critical Review of the state of the art of biodegradable plastics covers the environmental and socio-economic impact of plastics, government policies, standards and certifications, physico-chemical properties, and analytical techniques, highlighting the potential of bioplastics, but also the challenges and barriers towards their commercialization.

[Reviews]
Dr. Layla Filiciotto, Prof. Dr. Gadi Rothenberg
ChemSusChem, https://doi.org/10.1002/cssc.202002044. Read article.

The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders

The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders

Since its discovery in 1998, the orexin system has been of interest to the research community as a potential therapeutic target for the treatment of sleep/wake disorders. Herein we describe our efforts leading to the identification of daridorexant, which successfully finished two pivotal phase 3 clinical trials for the treatment of insomnia disorders.

[Full Papers]
Dr. Christoph Boss, Dr. John Gatfield, Dr. Christine Brotschi, Dr. Bibia Heidmann, Dr. Thierry Sifferlen, Dr. Markus von Raumer, Dr. Gunther Schmidt, Dr. Jodi T. Williams, Dr. Alexander Treiber, Dr. Catherine Roch
ChemMedChem, https://doi.org/10.1002/cmdc.202000453. Read article.

Accessing p-Hydroxycinnamic Acids: Chemical Synthesis, Biomass Recovery, or Engineered Microbial Production?

Accessing p-Hydroxycinnamic Acids: Chemical Synthesis, Biomass Recovery, or Engineered Microbial Production?

Make a choice: p-Hydroxycinnamic acids are of wide interest for various markets. Currently, their availability remains limited. Herein, an overview of the different strategies for (1) their synthesis through eco-compatible process, (2) their extraction from agricultural co-product, and (3) their bioproduction, is given and discussed.

[Reviews]
Amandine L. Flourat, Jeanne Combes, Claire Bailly-Maitre-Grand, Kévin Magnien, Prof. Arnaud Haudrechy, Prof. Jean-Hugues Renault, Prof. Florent Allais
ChemSusChem, https://doi.org/10.1002/cssc.202002141. Read article.

Ultrafast Inside-Out NMR Assessment of Rechargeable Cells

Ultrafast Inside-Out NMR Assessment of Rechargeable Cells

In a blink: This work presents a technique for ultrafast and nondestructive rechargeable cell diagnostics. The method is based on sensing the changes in the magnetic susceptibility properties of battery materials via nuclear magnetic resonance spectroscopy with minimal hardware. Within less than one second, cells can be classified with regard to cathode material and state of charge. This technique may provide cell diagnostics at different stages of a battery's life cycle.

[Articles]
Dr. Roberta Pigliapochi, Dr. Stefan Benders, Dr. Emilia V. Silletta, Dr. Stephen L. Glazier, Elizabeth Lee, Prof. Jeff Dahn, Prof. Alexej Jerschow
Batteries & Supercaps, https://doi.org/10.1002/batt.202000200. Read article.

An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity

An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity

A next-generation aminoglycoside antibiotic based on the apralog concept is presented that displays excellent activity in vivo and in vitro, excellent across-the-board selectivity for the inhibition of bacterial over hybrid eukaryotic ribosomes, minimal ototoxicity in an ex vivo model, and which circumvents AAC(3)-IV, the only current aminoglycoside-modifying enzyme acting on the parent.

[Communications]
Amr Sonousi, Jonathan C. K. Quirke, Dr. Prabuddha Waduge, Tanja Janusic, Marina Gysin, Klara Haldimann, Dr. Shan Xu, Dr. Sven N. Hobbie, Prof. Dr. Su-Hua Sha, Prof. Dr. Jochen Schacht, Prof. Dr. Christine S. Chow, Prof. Dr. Andrea Vasella, Prof. Dr. Erik C. Böttger, Prof. Dr. David Crich
ChemMedChem, https://doi.org/10.1002/cmdc.202000726. Read article.

Co-staining of KCa3.1 Channels in NSCLC Cells with a Small-Molecule Fluorescent Probe and Antibody-Based Indirect Immunofluorescence

Co-staining of KCa3.1 Channels in NSCLC Cells with a Small-Molecule Fluorescent Probe and Antibody-Based Indirect Immunofluorescence

Open vs. closed: The KCa3.1 channel is involved in critical steps of the metastatic cascade. Analyzing KCa3.1 channel expression has predictive power with respect to patient survival. Novel fluorescently labeled small-molecule imaging probes were able to stain KCa3.1 channels in NSCLC cells selectively and efficiently. Co-staining using antibody-based indirect immunofluorescence did not lead to the expected overlapping punctate staining pattern. This observation was explained by docking studies showing that the antibody and the novel imaging probes label different channel populations, closed and open channels, respectively.

[Full Papers]
Dr. Kathrin Brömmel, Sarah Maskri, Dr. Etmar Bulk, Dr. Zoltan Pethő, Dr. Marius Rieke, Prof. Dr. Thomas Budde, Dr. Oliver Koch, Prof. Dr. Albrecht Schwab, Prof. Dr. Bernhard Wünsch
ChemMedChem, https://doi.org/10.1002/cmdc.202000652. Read article.

Regioselective Synthesis of Halotriazoles and their Utility in Metal Catalyzed Coupling Reactions

Regioselective Synthesis of Halotriazoles and their Utility in Metal Catalyzed Coupling Reactions

This review summarizes important developments on the synthesis of halotriazoles using metal mediated alkyne azide cycloaddition. Various coupling reactions of halotriazoles, which give regioselective access to trisubstituted triazoles are discussed.

[Minireview]
Prof. Dr. Santosh J. Gharpure, Dr. Sudi Naveen, Rupali S. Chavan, Padmaja
European Journal of Organic Chemistry, https://doi.org/10.1002/ejoc.202000973. Read article.

An Efficient Route to Symmetrical and Unsymmetrical Disulfide, Thioether, and Hydrocarbon Cyclophanes

An Efficient Route to Symmetrical and Unsymmetrical Disulfide, Thioether, and Hydrocarbon Cyclophanes

We showcase a 3-step approach - supramolecular self-assembly, covalent capture, and photochemical sulfur extrusion - to generate a series of disulfide, thioether, and hydrocarbon cyclophanes. An added sorting step allows isolation of unsymmetrical “social sorted” disulfide products, which are converted to hydrocarbon analogs of [2,2,2]paracyclophane featuring both phenyl and biphenyl linkers.

[Full Papers]
Ngoc-Minh Phan, Trevor A. Shear, Dr. Lev N. Zakharov, Prof. Dr. Darren W. Johnson
European Journal of Organic Chemistry, https://doi.org/10.1002/ejoc.202001242. Read article.

Gas-Phase Photoelectrocatalysis Mediated by Oxygen Ions for Uphill Conversion of Greenhouse Gases

Gas-Phase Photoelectrocatalysis Mediated by Oxygen Ions for Uphill Conversion of Greenhouse Gases

That's gas! This study reports a gas-phase photoelectrochemical (GPEC) system in which photoanode and photocathode materials are coated on each side with a pellet of the oxygen-ion conductor yttria-stabilized zirconia (meaning light irradiation is feasible on both sides). Dry reforming of methane was investigated as a model gas-phase reaction, in which greenhouse gases are efficiently converted into syngas by light irradiation.

[Articles]
Masaru Kushida, Dr. Akira Yamaguchi, Yohei Cho, Prof. Dr. Takeshi Fujita, Prof. Dr. Hideki Abe, Prof. Dr. Masahiro Miyauchi
ChemPhotoChem, https://doi.org/10.1002/cptc.202000228. Read article.

Metal-Organic Framework MIL-125 Derived Mg2+-Doped Mesoporous TiO2 for Photocatalytic CO2 Reduction

Metal-Organic Framework MIL-125 Derived Mg2+-Doped Mesoporous TiO2 for Photocatalytic CO2 Reduction

On the surface: Mg2+ doped mesoporous TiO2 photocatalysts derived from MIL-125 have been employed for photocatalytic CO2 reduction. Compared with commercially available P25 TiO2 materials, Mg2+ doped mesoporous TiO2 delivered up to ∼20-fold enhancement in photocatalytic CO2 reduction efficiency. Material characterization suggests that Mg2+ doping on MIL-125 leads to higher surface area and facilitates the generation of surface Ti3+, which develops more reactive sites and improves charge-transfer properties of the photocatalysts.

[Articles]
Xuhui Feng, Dr. Fuping Pan, Dr. Peng Zhang, Xiao Wang, Prof. Hong-Cai Zhou, Prof. Yongheng Huang, Prof. Ying Li
ChemPhotoChem, https://doi.org/10.1002/cptc.202000181. Read article.

Synthesis of anti-Markovnikov Alcohols via Epoxidation and Hydrogenation of Styrenes using Photocatalytically Generated Redox Equivalents

Synthesis of anti-Markovnikov Alcohols via Epoxidation and Hydrogenation of Styrenes using Photocatalytically Generated Redox Equivalents

Test the water: The anti-Markovnikov addition of water to styrene is realized by the photocatalytic in situ generation of redox equivalents using Au/TiO2 as photocatalyst. By sequential epoxidation and regioselective epoxide opening various 2-phenylethanol derivatives are obtained from the corresponding styrenes. Alteration between H2O2 and H2 production for the corresponding reaction step is achieved applying either aerobic or anaerobic photocatalysis conditions, respectively.

[Articles]
Andreas Graml, Prof. Dr. Burkhard König
ChemPhotoChem, https://doi.org/10.1002/cptc.202000205. Read article.

Hydrostatic-Pressure-Controlled Molecular Recognition: A Steroid Sensing Case Using Modified Cyclodextrin

Hydrostatic-Pressure-Controlled Molecular Recognition: A Steroid Sensing Case Using Modified Cyclodextrin

Be my guest: The conformational changes of fluorophore-modified cyclodextrin (CD) under hydrostatic pressurization, i. e., fluorophore-in, fluorophore-out, and fluorophore-out with guest, are reported. The guest molecule inclusion in the CD cavity induces the formation of the fluorophore-out with guest under high pressure.

[Articles]
Dr. Akihisa Miyagawa, Hiroshi Yoneda, Hiroaki Mizuno, Prof. Munenori Numata, Prof. Tetsuo Okada, Prof. Gaku Fukuhara
ChemPhotoChem, https://doi.org/10.1002/cptc.202000204. Read article.

Broad-Spectrum Antifungal Agents: Fluorinated Aryl- and Heteroaryl-Substituted Hydrazones

Broad-Spectrum Antifungal Agents: Fluorinated Aryl- and Heteroaryl-Substituted Hydrazones

Antifungal drug development: The synthesis and biological activity of fluorinated aryl- and heteroaryl-substituted monohydrazones are presented. In most cases, the antifungal activity of these new compounds exceeded those of reference drugs against various fungal strains tested. All the lead compounds exhibited better safety profiles and there was low incident of resistance development. Thus, these fluorinated aryl- and heteroaryl-substituted monohydrazones could lead to the development of novel antifungal agents.

[Full Papers]
Dr. Nishad Thamban Chandrika, Emily K. Dennis, Katelyn R. Brubaker, Dr. Stefan Kwiatkowski, Prof. David S. Watt, Prof. Sylvie Garneau-Tsodikova
ChemMedChem, https://doi.org/10.1002/cmdc.202000626. Read article.

Synthesis of New Energetic Materials Based on Furazan Rings and Nitro-NNO-azoxy Groups

Synthesis of New Energetic Materials Based on Furazan Rings and Nitro-NNO-azoxy Groups

Methods for the synthesis of several novel energetic materials based on furazan cycle and nitro-NNO-azoxy group have been developed. Compounds obtained display high calculated energetic properties (ΔH°f=600-892 kcal kg−1, vD=8.07-9.40 km s−1 and PC-J=27.4-43.4 GPa) and have promising specific impulses in model solid propellant formulations.

[Full Papers]
Nikita E. Leonov, Dr. Michael S. Klenov, Dr. Oleg V. Anikin, Prof. Aleksandr M. Churakov, Dr. Yurii A. Strelenko, Dr. Alexey A. Voronin, David B. Lempert, Dr. Nikita V. Muravyev, Dr. Ivan V. Fedyanin, Sergei E. Semenov, Prof. Vladimir A. Tartakovsky
ChemistrySelect 2020, 5, 12243. Read article.

Efficacy of Fatty Acid Amide Derivatives against Listeria monocytogenes

Efficacy of Fatty Acid Amide Derivatives against Listeria monocytogenes

The carboxylic acid functional group of lauric, myristic and palmitic acids was modified with heterocyclic amines (pyrrolidine and piperidine) to make fatty acid amide derivatives. Pyrrolidine amide derivatives of lauric and myristic acids exhibited time and concentration dependent excellent inhibitory activity against Listeria monocytogenes strains. These fatty acid amide derivatives could be considered as alternative and bio-based antimicrobial agents that can control Listeria growth in food products.

[Full Papers]
Dr. Hailemichael O. Yosief, Dr. Syed A. Hussain, Dr. Majher I. Sarker, Dr. Bassam A. Annous
ChemistrySelect 2020, 5, 12261. Read article.

Enhancement of Structural, Electrochemical, and Thermal Properties of Ni-Rich LiNi0.85Co0.1Mn0.05O2 Cathode Materials for Li-Ion Batteries by Al and Ti Doping

Enhancement of Structural, Electrochemical, and Thermal Properties of Ni-Rich LiNi0.85Co0.1Mn0.05O2 Cathode Materials for Li-Ion Batteries by Al and Ti Doping

To be rich and doped: The influence of Al and Ti doping on the structural, electrochemical and thermal properties of NCM85 cathode materials is studied. Both Al- and Ti-doped cathode materials show superior electrochemical, structural and thermal properties compared to the reference. The coherence between the different properties is discussed and demonstrated.

[Articles]
Yehonatan Levartovsky, Xiaohan Wu, Christoph Erk, Sandipan Maiti, Judith Grinblat, Michael Talianker, Prof. Doron Aurbach
Batteries & Supercaps, https://doi.org/10.1002/batt.202000191. Read article.

Accelerated Ripening in Chemically Fueled Emulsions

Accelerated Ripening in Chemically Fueled Emulsions

Chemically fueled emulsions are solutions with droplets made of phase-separated molecules activated and deactivated by a chemically-fueled reaction cycle. Such systems are present in biology, but synthetic analogues are limited. Here, we describe human-made chemically fueled emulsions, and we find a surprising behavior, i.e., the dynamics of droplet growth is regulated by the kinetics of the fuel-driven reaction cycle. Combining experiments and theory, we elucidate the underlying mechanism, which relies on the acceleration of Ostwald ripening.

[Full Papers]
Dr. Marta Tena-Solsona, Jacqueline Janssen, Dr. Caren Wanzke, Fabian Schnitter, Hansol Park, Dr. Benedikt Rieß, Prof. Dr. Julianne M. Gibbs, Dr. Christoph A. Weber, Prof. Dr. Job Boekhoven
ChemSystemsChem, https://doi.org/10.1002/syst.202000034. Read article.

Anion Receptors for the Discrimination of ATP and ADP in Biological Media

Anion Receptors for the Discrimination of ATP and ADP in Biological Media

Bind and signal: This Minireview describes progress in the development of molecular receptors that can bind and discriminate between ATP and ADP. Particular focus is given to the application of receptors for quantifying ATP or ADP levels in biological media, tracking ATP levels (or the ATP/ADP ratio) in cells using fluorescence microscopy, or real-time monitoring of enzyme reactions involving ATP and ADP in vitro.

[Minireviews]
Dr. Stephen J. Butler, Prof. Katrina A. Jolliffe
ChemPlusChem, https://doi.org/10.1002/cplu.202000567. Read article.

Synthesis of Cyclen-Functionalized Ethenylene-Based Periodic Mesoporous Organosilica Nanoparticles and Metal-Ion Adsorption Studies

Synthesis of Cyclen-Functionalized Ethenylene-Based Periodic Mesoporous Organosilica Nanoparticles and Metal-Ion Adsorption Studies

Why would heavy metal ever go away? Cyclen-functionalized ethenylene-based periodic mesoporous organosilica nanoparticles were prepared for heavy metal removal from model solutions. The kinetics and isotherms of adsorption of nickel and cobalt were determined, and these nanomaterials showed high uptake of metals (up to 3.9 mmol g−1). They demonstrated pronounced selectivity in the separation of rare earth elements (e.g., neodymium and samarium) from late transition metals, e.g. Ni(II) and Co(II), by adsorption and even more so by controlled desorption. More information can be found in the Full Paper by Jean-Olivier Durand, Roser Pleixats, Gulaim Seisenbaeva et al.

[Cover Pictures]
Hao Li, Dr. Ani Vardanyan, Dr. Clarence Charnay, Dr. Laurence Raehm, Prof. Gulaim Seisenbaeva, Prof. Roser Pleixats, Dr. Jean-Olivier Durand
ChemNanoMat, https://doi.org/10.1002/cnma.202000490. Read article.

Large-scale Synthesis of Uniform and Shape-tunable ZnO/Polysiloxane Janus Micromotors Powered by Visible Light and Pure Water

Large-scale Synthesis of Uniform and Shape-tunable ZnO/Polysiloxane Janus Micromotors Powered by Visible Light and Pure Water

A new method is proposed for large-scale synthesis of uniform Janus ZnO@PTPM micromotors, of which the shapes are readily tuned by adjusting the chemicals used in the synthesis. The resulting micromotors move autonomously under visible light and in pure water, and form distinct collective structures in dense state.

[Communications]
Wenqing Xie, Chao Zhou, Xiaoliang Zhang, Dr. Sinan Du, Prof. Wei Wang, Dr. Huaguang Wang, Prof. Zexin Zhang
ChemNanoMat, https://doi.org/10.1002/cnma.202000488. Read article.

Li1.5Al0.5Ge1.5(PO4)3 Ceramic Based Lithium-Sulfur Batteries with High Cycling Stability Enabled by a Dual Confinement Effect for Polysulfides

Li1.5Al0.5Ge1.5(PO4)3 Ceramic Based Lithium-Sulfur Batteries with High Cycling Stability Enabled by a Dual Confinement Effect for Polysulfides

Closed borders: A Li1.5Al0.5Ge1.5(PO4)3 (LAGP) ceramic is adopted to block the migration of polysulfides in Li−S batteries, with solvent-in-salt wetting the electrode/ceramic interfaces. Owing to suppressed dissolution of polysulfides in SIS, the semi-solid-state Li−S batteries show superior capacity retention and long cycling life.

[Articles]
Dr. Qing Wang, Dr. Yang Lu, Dr. Jun Jin, Dr. Chunhua Chen, Dr. Zhaoyin Wen
ChemElectroChem 2020, 7, 4093. Read article.

A Versatile In-Situ Electron Paramagnetic Resonance Spectro-electrochemical Approach for Electrocatalyst Research

A Versatile In-Situ Electron Paramagnetic Resonance Spectro-electrochemical Approach for Electrocatalyst Research

A novel electrode design for combined in-situ electrochemical electron paramagnetic resonance experiments is presented. The use of a transparent Indium Tin Oxide on PET semiconductor as a substrate for electrocatalyst deposition and in-situ investigation of radical intermediates provides unique opportunities in catalyst research. The electrode approaches the maximum available surface area in the electrolytic flat cell resulting in superior sensitivity.

[Articles]
Sander Neukermans, Mohammad Samanipour, Dr. H. Y. Vincent Ching, Dr. Jonas Hereijgers, Prof. Dr. Sabine Van Doorslaer, Prof. Dr. Annick Hubin, Prof. Dr. Tom Breugelmans
ChemElectroChem, https://doi.org/10.1002/celc.202001193. Read article.

Interconnected Two-dimensional Arrays of Niobium Nitride Nanocrystals as Stable Lithium Host

Interconnected Two-dimensional Arrays of Niobium Nitride Nanocrystals as Stable Lithium Host

2D host: A stable Li-metal anode is enabled by interconnected 2D arrays of niobium nitride nanocrystals as Li host with a high Coulombic efficiency (>99 %) after 500 cycles. Coupled with lithium nickel-manganese-cobalt oxide, the full Li-metal battery shows long-term cycling stability under practical conditions.

[Communications]
Dr. Xu Xiao, Prof. Dr. Wei Yao, Dr. Jun Tang, Chuanfang Liu, Ruqian Lian, Dr. Patrick Urbankowski, Mark Anayee, Shijie He, Dr. Jianmin Li, Dr. Hao Wang, Prof. Yu Gao, Prof. Yingjin Wei, Prof. Yury Gogotsi
Batteries & Supercaps, https://doi.org/10.1002/batt.202000186. Read article.

Electrochemical Performance and Mechanism of Calcium Metal-Organic Battery

Electrochemical Performance and Mechanism of Calcium Metal-Organic Battery

Work in progress: A proof-of-concept Ca metal-organic battery was demonstrated through the combination of anthraquinone polymer cathode and novel calcium tetrakis(hexafluoroisopropyl)borate salt. The anthraquinone electrochemical group undergoes reversible reduction of carbonyl bond during discharge and is coordinated by both Ca2+ and Ca[B(hfip)4]+ cations, with much higher contribution of the former. Continued cycling of the battery led to overpotential build-up, which originated on the Ca metal anode. These findings point the need for further electrolyte development with improved Ca metal compatibility and Ca2+ dissociation ability.

[Articles]
Dr. Jan Bitenc, Antonio Scafuri, Dr. Klemen Pirnat, Dr. Matic Lozinšek, Dr. Ivan Jerman, Prof. Dr. Jože Grdadolnik, Dr. Bernard Fraisse, Dr. Romain Berthelot, Prof. Dr. Lorenzo Stievano, Prof. Dr. Robert Dominko
Batteries & Supercaps, https://doi.org/10.1002/batt.202000197. Read article.

Catalytic Access to Succinimide Products Containing Stereogenic Quaternary Carbons

Catalytic Access to Succinimide Products Containing Stereogenic Quaternary Carbons

Succinimide product diversification is explored with an emphasis on providing highly enantioenriched succinimide products with stereogenic quaternary carbons and an easy to remove nitrogen protecting group. To achieve this, unsymmetrical α-branched aldehydes (1.2 equiv) were added to N-benzylmaleimide (1.0 equiv) using 5 mol % of a commercially available catalyst: O−tBu−L-threonine.

[Full Papers]
Prof. Abdul Sadiq, Prof. Thomas C. Nugent
ChemistrySelect 2020, 5, 11934. Read article.

Nickel-Based Metal-Organic Framework/Crosslinked Tubular Poly(3,4-ethylenedioxythiophene) Composite as an Electrocatalyst for the Detection of Gallic Acid and Tinidazole

Nickel-Based Metal-Organic Framework/Crosslinked Tubular Poly(3,4-ethylenedioxythiophene) Composite as an Electrocatalyst for the Detection of Gallic Acid and Tinidazole

Double sense: A nickel-based metal-organic framework embedded in tubular poly(3,4-ethylenedioxythiophene) (Ni-MOF/T-PEDOT) electrocatalyst is synthesized through an in situ method. Ni-MOF embedded into the crosslinked structure of T-PEDOT shows enhanced electrocatalytic properties. The sensor shows a wider linear range and high sensitivity for gallic acid in 0.1 M PBS (pH=3) solution. It also has a wider linear range for tinidazole in 0.04 M BR (pH=6) solution. Satisfactory results are achieved for gallic acid and tinidazole in human serum and urine.

[Articles]
Dr. Haixu Wang, Dr. Xiaogeng Feng, Prof. Xiangjie Bo, Prof. Ming Zhou, Prof. Liping Guo
ChemElectroChem 2020, 7, 4031. Read article.

Research Progress of Silicon/Carbon Anode Materials for Lithium-Ion Batteries: Structure Design and Synthesis Method

Research Progress of Silicon/Carbon Anode Materials for Lithium-Ion Batteries: Structure Design and Synthesis Method

Foundation structure: Lithium ion batteries (LIBs) are considered to be the most competitive recyclable energy storage devices at present and in the future. Silicon/carbon anodes have been widely considered and studied, owing to their various advantages. This review highlights the major research progresses and achievements of silicon/carbon anode materials for LIBs. Structure design, synthesis methods as well as issues and challenges are discussed.

[Reviews]
Xinzhi Li, Meng Zhang, Prof. Shuxia Yuan, Prof. Chunxiang Lu
ChemElectroChem, https://doi.org/10.1002/celc.202001060. Read article.

An Unsymmetrical Perylene Diimide Dye Modified Carbon Felt Electrode as A Novel Electrochemical Platform for Dopamine Detection

An Unsymmetrical Perylene Diimide Dye Modified Carbon Felt Electrode as A Novel Electrochemical Platform for Dopamine Detection

The necessity yet challenges at dopamine detection forces researchers to be more creative day by day. In order to make appropriate dopamine detection, in this work, PDI-C8SAc was introduced as a modifier into carbon felt electrode and as a result, PDI-C8Sac/CFE was obtained. After the optimization of experimental parameters of developed electrochemical dopamine sensor, it was applied for dopamine detection in injection samples.

[Full Papers]
Dr. Tuğba Ören Varol, Okan Avcı, Özgül Haklı, Dr. Chenming Xue, Dr. Quan Li, Prof. Dr. Ülkü Anık
ChemistrySelect 2020, 5, 11698. Read article.

Synthesis of Two-dimensional Metallic Nanosheets: From Elemental Metals to Chemically Complex Alloys

Synthesis of Two-dimensional Metallic Nanosheets: From Elemental Metals to Chemically Complex Alloys

Two-dimensional (2D) metals and alloys, as a newcomer to the family of 2D materials, have ushered in rapid development in recent years owing to their unique physical, chemical properties and potential applications in catalysis, bio-imaging, photothermal therapy, sensing and nanodevices. Here we provide a comprehensive review on the synthesis of 2D metals hitherto reported, from elemental metals, chemically complex alloys to 2D heterogeneous structures. Meanwhile, we also offer our perspectives on the challenges facing this field.

[Minireviews]
Dr. Qing Yu, Prof. Yong Yang
ChemNanoMat, https://doi.org/10.1002/cnma.202000448. Read article.

N-Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase

N-Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase

Odd skills: Mutational analysis, in silico studies, and in vitro reconstitution revealed that GliF from A. fumigatus is a novel cytochrome P450 monooxygenase catalyzing an unprecedented N-heterocyclization reaction to form the hydroindole ring scaffold of the important virulence factor gliotoxin.

[Communications]
Daniel H. Scharf, Pranatchareeya Chankhamjon, Dr. Kirstin Scherlach, Jan Dworschak, Thorsten Heinekamp, Martin Roth, Prof. Axel A. Brakhage, Prof. Dr. Christian Hertweck
ChemBioChem, https://doi.org/10.1002/cbic.202000550. Read article.

Site-Selective Peptide Macrocyclization

Site-Selective Peptide Macrocyclization

Bye-bye, by-products: Macrocyclic peptides are useful in pharmaceuticals, but their synthesis is challenging due to the formation of side products. Here, we review methods for the creation of cyclic peptides in a site-selective fashion thus minimizing side reactions. A new exclusively intramolecular, site-selective “CyClick” strategy synthesizes cyclic peptides in high yields without generating unwanted dimers and oligomers due to intermolecular reactions.

[Minireviews]
Rachel Wills, Victor Adebomi, Prof. Dr. Monika Raj
ChemBioChem, https://doi.org/10.1002/cbic.202000398. Read article.

Trapping Transient Protein Species by Genetic Code Expansion

Trapping Transient Protein Species by Genetic Code Expansion

Expansion of nature's toolkit by genetically encoded amino acids has enabled the production of proteins with tailored electronic and structural properties. This minireview highlights recent studies showing that noncanonical amino acids are powerful tools for capturing short-lived protein intermediates and accessing novel function.

[Minireviews]
Matthias Tinzl, Prof. Donald Hilvert
ChemBioChem, https://doi.org/10.1002/cbic.202000523. Read article.

NIR-Absorbing RuII Complexes Containing α-Oligothiophenes for Applications in Photodynamic Therapy

NIR-Absorbing RuII Complexes Containing α-Oligothiophenes for Applications in Photodynamic Therapy

Running rings round cancer: We report the first NIR-RuII photosensitizers found to be phototoxic to cancer cells, including highly pigmented melanoma cells. They incorporate a bis(1,8-naphthyridine)-based ligand, a bidentate thiophene-based ligand, and a monodentate 4-picoline ligand. Transient absorption measurements indicate that four thiophenes are required to access the 3ILCT state for eliciting photodynamic therapy effects.

[Full Papers]
Dr. Liubov M. Lifshits, John A. Roque III, Houston D. Cole, Prof. Dr. Randolph P. Thummel, Prof. Dr. Colin G. Cameron, Prof. Dr. Sherri A. McFarland
ChemBioChem, https://doi.org/10.1002/cbic.202000419. Read article.

Tuning the Ground and Excited State Dynamics of Hemithioindigo Molecular Motors by Changing Substituents

Tuning the Ground and Excited State Dynamics of Hemithioindigo Molecular Motors by Changing Substituents

In a spin: The unidirectional rotation mechanisms of three hemithioindigo based molecular motors are compared fully quantitatively over a dynamic range of twelve orders of magnitude in time.

[Full Papers]
Roland Wilcken, Dr. Ludwig Huber, Kerstin Grill, Dr. Manuel Guentner, Dr. Monika Schildhauer, Stefan Thumser, Prof. Dr. Eberhard Riedle, Prof. Dr. Henry Dube
Chemistry – A European Journal 2020, 26, 13507. Read article.

Shifting Towards αVβ6 Integrin Ligands Using Novel Aminoproline-Based Cyclic Peptidomimetics

Shifting Towards αVβ6 Integrin Ligands Using Novel Aminoproline-Based Cyclic Peptidomimetics

Filling the pocket moves selectivity: Bulky, hydrophobic RGD-flanking residues can enhance potency and selectivity of aminoproline-containing cyclopeptidomimetics targeting αVβ6 integrin receptors.

[Full Papers]
Kelly Bugatti, Dr. Agostino Bruno, Dr. Daniela Arosio, Prof. Dr. Andrea Sartori, Prof. Claudio Curti, Lisa Augustijn, Prof. Dr. Franca Zanardi, Prof. Dr. Lucia Battistini
Chemistry – A European Journal 2020, 26, 13468. Read article.

Rigidly Fused Spiro-Conjugated π-Systems

Rigidly Fused Spiro-Conjugated π-Systems

Spiro-fused π-systems have been increasingly gaining attention, owing to their unique photophysical properties, high thermal stability, and application potential as semiconductors. Recent breakthroughs in ladderized spirobifluorenes and indeno-spirobifluorenes, along with further spiro-condensed heteroatomic hydrocarbons, are provided. Additionally, a range of extended rigid spirobifluorene polymers, along with specific doubly linked spiro-systems with chiral character, are presented. Our summarized review is primarily focused on the chemical structures, photophysical properties, and single crystal packing patterns.Minireview by Baumgarten, Xia @mpi_polymer @HIT_China et al. on rigidly fused spiro-conjugated π-systems

[Minireviews]
Shihui Liu, Prof. Dr. Debin Xia, Prof. Dr. Martin Baumgarten
ChemPlusChem, https://doi.org/10.1002/cplu.202000467. Read article.

Nanostructures for Electrocatalytic CO2 Reduction

Nanostructures for Electrocatalytic CO2 Reduction

Change for the better: Recent research on 0D, 1D, 2D, and multi-component nanostructured materials for heterogeneous electrocatalytic CO2 conversion is summarized and discussed. The challenges and development prospects of nanostructured materials for CO2 conversion are also presented.

[Minireviews]
Dr. Ting Ouyang, Sheng Huang, Xiao-Tong Wang, Prof. Zhao-Qing Liu
Chemistry – A European Journal, https://doi.org/10.1002/chem.202000692. Read article.

Photo-switchable Fluorescence in Hydrogen-Bonded Liquid Crystals

Photo-switchable Fluorescence in Hydrogen-Bonded Liquid Crystals

Turn the light on: Supramolecular materials with reversible photo-switchable fluorescence were obtained by combining 4-alkoxystilbazoles with hydroxy benzoic acids. Using the photobasicity/acidity of the assemblies lead to fluorescent materials upon irradiation in the mesophase

[Communications]
Alexander Kappelt, Prof. Dr. Michael Giese
Chemistry – A European Journal 2020, 26, 13347. Read article.

Helicene Radicals: Molecules Bearing a Combination of Helical Chirality and Unpaired Electron Spin

Helicene Radicals: Molecules Bearing a Combination of Helical Chirality and Unpaired Electron Spin

Helicene radicals that realize both helical chirality and unpaired electron spin are intriguing components for novel synergic functions based on their electronic, photonic, and magnetic properties. This Minireview presents the synthesis, structures, and physicochemical properties of organic-based helicene radicals to provide valuable knowledge for their further developments.

[Minireviews]
Dr. Fumito Tani, Masahiro Narita, Prof. Dr. Toshihiro Murafuji
ChemPlusChem 2020, 85, 2093. Read article.

Enzyme Immobilization in Covalent Organic Frameworks: Strategies and Applications in Biocatalysis

Enzyme Immobilization in Covalent Organic Frameworks: Strategies and Applications in Biocatalysis

Enzyme immobilization in COFs: Covalent organic frameworks (COFs) are an emergent class of nanomaterials, designed by the covalent bonding of one or more organic building blocks, following the concepts of reticular chemistry. Recent advances of enzyme immobilization in COFs are presented. Important aspects related to the structure, the preparation and characterization of these composites are highlighted, as well as their applications in different areas such as heterogenous catalysis, sensor development and chiral resolution. Future perspectives of this field are also commented.

[Reviews]
Felipe L. Oliveira, Alexandre de S. França, Aline Machado de Castro, Prof. Rodrigo O. M. Alves de Souza, Prof. Pierre M. Esteves, Prof. Raoni Schroeder B. Gonçalves
ChemPlusChem 2020, 85, 2051. Read article.

Interlayer Doping in Layered Vanadium Oxides for Low-cost Energy Storage: Sodium-ion Batteries and Aqueous Zinc-ion Batteries

Interlayer Doping in Layered Vanadium Oxides for Low-cost Energy Storage: Sodium-ion Batteries and Aqueous Zinc-ion Batteries

The importance of interlayer doping on the electrochemical performances of various layered vanadium oxides is highlighted in this Minireview. We focus on the essential characteristics of ionic doping and molecular doping, and their different effects and preferences are also revealed for SIBs and AZIBs with different working environment. For the unsolved issues in this field, insightful understanding and prospects are provided to promote the further development of low-cost, large-scale energy storage.

[Minireviews]
Zhexuan Liu, Hemeng Sun, Prof. Liping Qin, Prof. Xinxin Cao, Prof. Jiang Zhou, Prof. Anqiang Pan, Prof. Guozhao Fang, Prof. Shuquan Liang
ChemNanoMat, https://doi.org/10.1002/cnma.202000384. Read article.

Phosphorescent Tris-Bidentate IrIII Complexes with N-Heterocyclic Carbene Scaffolds: Structural Diversity and Optical Properties

Phosphorescent Tris-Bidentate IrIII Complexes with N-Heterocyclic Carbene Scaffolds: Structural Diversity and Optical Properties

We have herein reviewed phosphorescent tris-bidentate IrIII complexes bearing N-heterocyclic carbene (NHC) ligands. Prompted by their great potential application in different fields, including light-emitting devices, electro-chemiluminescence, and biomedicine, interest in this class of compounds has rapidly grown in the recent past, thus providing an excellent class of photoactive compounds.

[Minireviews]
Anna Bonfiglio, Dr. Matteo Mauro
European Journal of Inorganic Chemistry 2020, 3427. Read article.

The Role of Particle Contact in Densification of FLASH Sintered Potassium Sodium Niobate

The Role of Particle Contact in Densification of FLASH Sintered Potassium Sodium Niobate

This work is about the FLASH sintering process and respective operating sintering mechanisms in lead-free piezoelectrics, namely in K0.5Na0.5NbO3 (KNN). Our study reveals the importance of pre-FLASH microstructure for the engineering of uniform, highly dense ceramics by FLASH. We show that isothermal steps, before the application of the electric field, induce a higher degree of densification on FLASH sintered KNN.

[Full Papers]
Ricardo Serrazina, Prof. Ana M. O. R. Senos, Prof. Luis Pereira, Dr. Julian S. Dean, Prof. Ian M. Reaney, Prof. Paula M. Vilarinho
European Journal of Inorganic Chemistry 2020, 3720. Read article.

Structure-Functional Analysis of Hydrogen Production Catalyzed by Molecular Cobalt Complexes with Pentadentate Ligands in Aqueous Solutions

Structure-Functional Analysis of Hydrogen Production Catalyzed by Molecular Cobalt Complexes with Pentadentate Ligands in Aqueous Solutions

Recent research on electro- and photocatalytic hydrogen production by Co complexes with pentadentate ligands was summarized. The structure-function relationships of the described Co catalysts were analyzed to provide insights into the details of hydrogen evolution and to facilitate the discovery of new catalysts for future practical applications.

[Minireview]
Dr. Ping Wang, Dr. Guangchao Liang, Prof. Charles Edwin Webster, Prof. Xuan Zhao
European Journal of Inorganic Chemistry 2020, 3534. Read article.

Contemporary Molecular Barium Chemistry

Contemporary Molecular Barium Chemistry

An up-to-date survey of the recent progress in the molecular chemistry of barium is presented. It covers the synthesis of well-defined, soluble barium complexes and their performance as homogeneous catalysts in a variety of reactions such as hydroelementations and dehydrocouplings.

[Review]
Peter M. Chapple, Dr. Yann Sarazin
European Journal of Inorganic Chemistry 2020, 3321. Read article.