Dual Improvement of β-MnO2 Oxygen Evolution Electrocatalysts via Combined Substrate Control and Surface Engineering

β-MnO2 nanostructures, eventually decorated with Co3O4 or Fe2O3 nanoparticles, are grown by a plasma-assisted strategy on conductive glasses and porous Ni foams, and investigated as catalysts for the oxygen evolution reaction. The combined control over substrate properties and β-MnO2 surface decoration yields outstanding functional performances, paving the way to real-world applications in sustainable energy conversion processes.

[Full Papers]

Dr. Lorenzo Bigiani, Prof. Alberto Gasparotto, Prof. Chiara Maccato, Prof. Cinzia Sada, Prof. Johan Verbeeck, Dr. Teresa Andreu, Prof. Juan Ramón Morante, Dr. Davide Barreca

doi.org/10.1002/cctc.202000999

Butane Dry Reforming Catalyzed by Cobalt Oxide Supported on Ti2AlC MAX Phase

Take it to the MAX: The reaction of carbon dioxide with butane to give syn-gas is a valid method for converting CO2 into something useful and is catalyzed efficiently by cobalt oxide supported on a MAX phase.

[Full Papers]

Maria Ronda-Lloret, Dr. Vijaykumar S. Marakatti, Dr. Willem G. Sloof, Dr. Juan José Delgado, Prof. Dr. Antonio Sepúlveda-Escribano, Dr. Enrique V. Ramos-Fernandez, Dr. Gadi Rothenberg, Dr. N. Raveendran Shiju

doi.org/10.1002/cssc.202001633

Productive Syntheses of Privileged Scaffolds Inspired by the Recognition of a Diels-Alder Pattern Common to Three Classes of Natural Products

Natural products-inspired chemistry: Identification of a common Diels-Alder pattern in three classes of bioactive natural products led to the discovery of very productive syntheses of stereochemically rich and functionally dense scaffolds for the construction of libraries of molecules of therapeutic interest.

[Communications]

Dr. Eduard Badarau, Dr. K. Harsha Vardhan Reddy, Dr. Aurore Loudet, Dr. Charles Simon, Dr. Laurent Trembleau, Dr. Stijn Claerhout, Dr. Etienne Pair, Stéphane Massip, Dr. Philippe Breton, Dr. Brigitte Lesur, Dr. Solo Goldstein, Dr. Jean-Marie Fourquez, Dr. Jean Michel Henlin, Prof. Léon Ghosez

doi.org/10.1002/chem.202002372

MOF-derived/zeolite hybrid catalyst for the production of light olefins from CO2

CO2 transformation: In−Zr MOF co-calcined along with small pore zeolites (i. e. SSZ-13) is more efficient than the physically mixed (co-precipitated) In−Zr oxides in the direct transformation of CO2 into light olefins, obtaining 100 mmol of light olefins per gram of In per hour.

[Full Papers]

Dr. Nuria Martín, Ander Portillo, Dr. Ainara Ateka, Dr. Francisco G. Cirujano, Dr. Lide Oar-Arteta, Prof. Andrés T. Aguayo, Prof. Michiel Dusselier

doi.org/10.1002/cctc.202001109

Recent Advances in Heterogeneous Catalysis for Ammonia Synthesis

TOC: This review will give insights on recent development in advanced materials such as electrides, hydrides, nitrides, oxides and oxy-hydrides-nitrides as support and active component of Ru based catalyst in NH3 synthesis at milder reaction conditions. Electrides, hydrides, nitrides and oxides with their promising unique properties of reversible electron, hydride, nitride and oxide vacancies storage have tremendously improved Ru based catalysts efficiency. Perceptions on these materials and their mechanism digs towards finding a realistic catalyst for NH3 synthesis.

[Reviews]

Dr. Vijaykumar S. Marakatti, Prof. Eric M. Gaigneaux

doi.org/10.1002/cctc.202001141

High-Pressure Operando UV-Vis Micro-Spectroscopy of Coke Formation in Zeolite-based Catalyst Extrudates during the Transalkylation of Aromatics

Zeolite catalysis: A new methodology was developed to study the binder effect in catalyst extrudates at different reaction pressures using operando UV-vis micro-spectroscopy coupled with on-line gas chromatography. We studied the transalkylation of toluene with 1,2,4-trimethylbenzene on H-ZSM-5-containing extrudates at 1 or 5 bar. Using this technique, it was revealed that the binder material significantly influenced catalyst deactivation.

[Full Papers]

Suzanna P. Verkleij, Dr. Gareth T. Whiting, Dr. Sonia Parres Esclapez, Dr. Shiwen Li, Dr. Machteld M. Mertens, Dr. Marcel Janssen, Dr. Anton-Jan Bons, Dr. Martijn Burgers, Prof. Bert M. Weckhuysen

doi.org/10.1002/cctc.202000948

Peptidyl Acyloxymethyl Ketones as Activity-Based Probes for the Main Protease of SARS-CoV-2

Probe goes viral. The SARS-CoV-2 main protease is an attractive drug target to combat the causative agent of covid19. We report activity-based probes of this protease that are selective even in the presence of a human proteome. These reagents will allow detection of the Mpro as well as verification of target engagement by antiviral drugs against SARS-CoV-2.

[Full Papers]

Merel A. T. van de Plassche, Dr. Marta Barniol-Xicota, Prof. Dr. Steven H. L. Verhelst

doi.org/10.1002/cbic.202000371

Targeting G Protein-Coupled Receptors with Magnetic Carbon Nanotubes: The Case of the A3 Adenosine Receptor

Holding on to everything: A3 adenosine receptor ligands conjugated to Fe-filled carbon nanotubes were developed to target specific cancer cell lines for cancer magnetic cell sorting and thermal therapy. The nanostructure was able to efficiently bind to the A3 adenosine receptors, unfortunately, when interfaced with cells, the conjugates did not displayed selectivity for those overexpressing the receptor.

[Full Papers]

Dr. Florent Pineux, Dr. Stephanie Federico, Prof. Karl-Norbert Klotz, Sonja Kachler, Dr. Carine Michiels, Dr. Mattia Sturlese, Prof. Maurizio Prato, Prof. Giampiero Spalluto, Prof. Stefano Moro, Davide Bonifazi

doi.org/10.1002/cmdc.202000466

The Fe4+/3+ redox mechanism in NaFeO2: A simultaneous operando Nuclear Resonance and X-ray Scattering study

Operando Nuclear Forward and X-ray Scattering are simultaneously applied for the first time to study the electrochemical mechanism in battery materials. Together with conventional 57Fe Mössbauer spectroscopy, they provide new insight on the desodiation of NaFeO2.

[Articles]

Dr. Marcus Fehse, Dr. Dimitrios Bessas, Dr. Abdelfattah Mahmoud, Dr. Aliou Diatta, Dr. Raphael P. Hermann, Prof. Lorenzo Stievano, Dr. Moulay Tahar Sougrati

doi.org/10.1002/batt.202000157

Alkaline Earth Metals Activate N2 and CO in Cubic Complexes Just Like Transition Metals: A Conceptual Density Functional Theory and Energy Decomposition Analysis Study

Alkaline earth complexes: The viability of alkaline earth metal-based N2 fixation is investigated. It is shown that the activation of N2 through complexation originates from the d-π back-donation. Within one row of the periodic table, the alkaline earth metal shows the strongest nucleophilic activation of the N2 ligand, confirming clear trends in proton affinities.

[Full Papers]

Tom Bettens, Sudip Pan, Frank De Proft, Gernot Frenking, Paul Geerlings

doi.org/10.1002/chem.202001585

Collective photothermal effect of Al2O3-supported spheroidal plasmonic Ru nanoparticle catalysts in the sunlight-powered Sabatier reaction

CO2 Reduction: Al2O3-supported plasmonic Ru nanoparticles efficiently catalyze the sunlight-powered low-temperature conversion of CO2 and H2 to CH4 (Sabatier reaction). The sharp rate increase at high Ru loadings in combination with experimental and theoretical studies indicate a collective photothermal heating that powers this reaction.

[Communications]

Roos Grote, Roberto Habets, Jelle Rohlfs, Dr. Francesc Sastre, Nicole Meulendijks, Dr. Man Xu, Dr. Marcel A. Verheijen, Dr. Ken Elen, Prof. An Hardy, Prof. Marlies K. Van Bael, Dr. Tim den Hartog, Prof. Pascal Buskens

doi.org/10.1002/cctc.202000795

Resonance Assisted Hydrogen Bonding Phenomenon Unveiled through Both Experiments and Theory: A New Family of Ethyl N-Salicylideneglycinate Dyes

The concept of Resonance-Assisted-Hydrogen-Bond (RAHB) is well-establisted in chemisty. Herein, the nature of RAHB effect have been unveiled for a new family of ethyl N-salicylideneglycinate dyes differing in the donor-acceptor properties. The result of combined experimental and theoretical research reveals the nature of RAHB and a direct relationship between the magnitude of RAHB and the strength of intramolecular O−CH⋅⋅⋅N bond, and, consequently, its influence on enol—keto equilibria and further on the photoluminescence and thermochromic properties. More information can be found in the Full Paper by M. P. Mitoraj, D. A. Safin, et al. (DOI: 10.1002/chem.202001551).

[Cover Pictures]

Dinara S. Shapenova, Alexey A. Shiryaev, Michael Bolte, Mercedes Kukułka, Dariusz W. Szczepanik, James Hooper, Maria G. Babashkina, Ghodrat Mahmoudi, Mariusz P. Mitoraj, Damir A. Safin

doi.org/10.1002/chem.202002769

Alkaline Earth Metals Activate N2 and CO in Cubic Complexes Just Like Transition Metals: A Conceptual Density Functional Theory and Energy Decomposition Analysis Study

Alkaline earth metals activate the fixation of N2 because of the π-backdonation from the metal to the ligand; a phenomenon often considered exclusive to transition metals. Conceptual DFT descriptors reveal an increased soft character of the outer N-atom in cubic and octahedral group II, IV, and VI complexes, compared to isolated N2. Quantitative EDA studies confirm increased proton affinities due to stronger (soft) orbital interactions between the N2-ligand and H+. More information can be found in the Full Paper by G. Frenking, P. Geerlings, et al. (DOI: 10.1002/chem.202001585).

[Cover Pictures]

Tom Bettens, Sudip Pan, Frank De Proft, Gernot Frenking, Paul Geerlings

doi.org/10.1002/chem.202003969

Resonance Assisted Hydrogen Bonding Phenomenon Unveiled through Both Experiments and Theory: A New Family of Ethyl N-Salicylideneglycinate Dyes

Photoluminescence and thermochromic properties of ethyl N-salicylideneglycinate dyes differing in donor-acceptor properties are driven by the well-established, in general chemistry, concept of π-electrons delocalization, that is, resonance assisted hydrogen bonding (RAHB), which is unveiled and deeply understood on the grounds of both experiment and theory.

[Full Papers]

Dinara S. Shapenova, Alexey A. Shiryaev, Michael Bolte, Mercedes Kukułka, Dariusz W. Szczepanik, James Hooper, Maria G. Babashkina, Ghodrat Mahmoudi, Mariusz P. Mitoraj, Damir A. Safin

doi.org/10.1002/chem.202001551

Recent Progress in Vibropolaritonic Chemistry

Vibrational strong coupling: When the vibrational modes of molecules couple strongly to the vacuum electric fields of a Fabry-Pérot (FP) cavity, new vibro-polaritonic states are formed. Vibrational strong coupling (VSC) has emerged as a new tool for modulating chemical reactions. This review article provides a comprehensive summary of the recent progress in VSC-modulated chemical reactions.

[Minireviews]

Prof. Dr. Kenji Hirai, Dr. James A. Hutchison, Prof. Dr. Hiroshi Uji-i

doi.org/10.1002/cplu.202000411

Cover Feature: Continuous Flow Organophosphorus Chemistry (Eur. J. Org. Chem. 33/2020)

The Cover Feature shows some current applications of flow chemistry for the preparation of value-added organophosphorus compounds. An update on the most recent and significant advances in continuous flow organophosphorus chemistry is presented herein with selected examples including lab scale methodology and total synthesis as well as the preparation of industrially relevant targets (including agrochemicals and pharmaceuticals). A section also discusses the inherent treats related to the production of organophosphorus chemical warfare agents, as well as potential applications for their chemical neutralization. More information can be found in the Minireview by J.-C. M. Monbaliu et al.

[Cover Picture]

Romain Morodo, Pauline Bianchi, Prof. Jean-Christophe M. Monbaliu

doi.org/10.1002/ejoc.202001149

Synthesis and Structural Characterization of Lanthanide-Containing Polytungsto-antimonate [{Sb33-O)2Ln(H2O)Ln(H2O)2}2(SbW10O37)2(SbW8O31)2]22- Molecules Deriving from the Decomposition of the [Sb8W36O132]24- Macroanion

Lanthanide incorporation in the {Sb8W36} macromolecule leads to the formation of eight stable isostructural “S” shape molecules with four isolated lanthanide centers.

[Full Papers]

Dr. Maxime Dufaye, Dr. Sylvain Duval, Dr. Gregory Stoclet, Dr. Dimitrije Mara, Dr. Rik Van Deun, Dr. Thierry Loiseau

doi.org/10.1002/ejic.202000613

Pd/Lewis Acid Synergy in Macroporous Pd@Na-ZSM-5 for Enhancing Selective Conversion of Biomass

Confinement effect: The synergy effect of Pd and Lewis acid sites confined in Pd@macroporous Na-ZSM-5 significantly enhance the catalytic selectivity in biomass conversion.

[Communications]

Jia-Wen Liu, Si-Ming Wu, Li-Ying Wang, Ge Tian, Yuan Qin, Jing-Xian Wu, Xiao-Fang Zhao, Yan-Xiang Zhang, Gang-Gang Chang, Lu Wu, Prof. Yue-Xing Zhang, Zhao-Fei Li, Cheng-Yu Guo, Christoph Janiak, Silvia Lenaerts, Prof. Xiao-Yu Yang

doi.org/10.1002/cctc.202000868

Multivalent Antibody-Recruiting Macromolecules: Linking Increased Binding Affinity with Enhanced Innate Immune Killing

Into the line of fire: Macromolecular antibody recruiting molecules can bind though multivalent interaction with endogenous antibodies and draw these to the surface of target cells or pathogen, thereby marking the latter for innate immune destruction.

[Minireviews]

Annemiek Uvyn, Prof. Dr. Bruno G. De Geest

doi.org/10.1002/cbic.202000261

Photon Transport and Hydrodynamics in Gas-Liquid Flows Part 1: Characterization of Taylor Flow in a Photo Microreactor

Simply geometry: The increase in conversion with gas content is connected to the liquid distribution in the channel rather than the rate of liquid recirculation or light scattering. While the photon flux per liquid volume increases, the optical pathlength in the liquid decreases.

[Articles]

Dr. Anca Roibu, Prof. Tom Van Gerven, Prof. Simon Kuhn

doi.org/10.1002/cptc.202000065

Photon Transport and Hydrodynamics in Gas-Liquid Flow Part 2: Characterization of Bubbly Flow in an Advanced-Flow Reactor

It's about time: The increase in conversion with gas content is mainly linked to the liquid residence time, which is larger than expected due to the gas-liquid hydrodynamics. While the photon flux per liquid volume is almost constant, the optical pathlength in the liquid decreases.

[Articles]

Dr. Anca Roibu, Dr. Clemens R. Horn, Prof. Tom Van Gerven, Prof. Simon Kuhn

doi.org/10.1002/cptc.202000066

Nonhydrolyzable Heptose Bis- and Monophosphate Analogues Modulate Pro-inflammatory TIFA-NF-κB Signaling

Small change, big difference: A series of nonhydrolyzable analogues of bacterial heptosides has been synthesized and assayed on whole cells. Interestingly, depending on the functional groups at the 7-position of the heptose scaffold and in the vicinity of the anomeric position, some molecules could trigger an inflammatory response whereas others were antagonists of heptose-1,7-bisphosphate.

[Full Papers]

Dr. Lina Liang, Tong-You Wade Wei, Pei-Yu Wu, Wouter Herrebout, Ming-Daw Tsai, Prof. Stéphane P. Vincent

doi.org/10.1002/cbic.202000319

Bacterial Cell Display as a Robust and Versatile Platform for Engineering Low-Affinity Ligands and Enzymes

Displaying enzymes and low-affinity binding proteins on the surface of the bacterial cell: A SNAP reporter together with the function-dependent labelling of the cell with cholesterol-linked DNA, allows systematic optimisation of cell display, making it a robust and flexible platform for the systematic evolution of XNA molecular biology.

[Full Papers]

Dr. Eszter Csibra, Dr. Marleen Renders, Prof. Dr. Vitor B. Pinheiro

doi.org/10.1002/cbic.202000203