A Decade of Indium-Catalyzed Multicomponent Reactions (MCRs)

Indium catalysis applied to multicomponent reactions is a thriving field in organic synthesis. In this work, we revisited the main achievements in indium-catalyzed multicomponent reactions, showcasing the versatility of the different indium-based catalysts, from simple indium powder, to inexpensive and easily available indium salts, to more complex heterogeneous catalytic systems, such as indium-based metal-organic frameworks and nanoparticles.

[Minireview]

Pedro Brandão, Prof. Dr. Anthony J. Burke, Prof. Dr. Marta Pineiro

doi.org/10.1002/ejoc.202000596

Syntheses, Structures and Magnetic Properties of Ferromagnetically/Antiferromagnetically Coupled Penta- and Hexanuclear Azido-Bridged Nickel(II) Coordination Compounds

Two pentanuclear and one related hexanuclear azide-based nickel(II) coordination clusters were synthesized using a bicompartmental Schiff base ligand under mild reaction conditions. The magnetic studies reveal overall dominating antiferromagnetic and ferromagnetic coupling in these systems, and the correlation between the crystal structures and magnetic properties is presented.

[Full Papers]

Dr. Anangamohan Panja, Sarmistha Adak, Paula Brandão, Dr. Ľubor Dlháň, Prof. Dr. Roman Boča

doi.org/10.1002/ejic.202000045

Supported Ionic Liquids for the Efficient Removal of Acetylsalicylic Acid from Aqueous Solutions

New materials based on silica functionalized with ionic liquids (SILs) were synthetized and characterized aiming their use in the removal of pharmaceuticals from aqueous samples. The obtained results disclose that the best SIL has high capacity for the adsorption/removal of acetylsalicylic acid, with no negative cytotoxic impacts towards human cell lines, reinforcing its potential to treat water samples.

[Full Papers]

Dr. Sandra C. Bernardo, Beatriz R. Araújo, Dr. Ana C. A. Sousa, Rafael A. Barros, Dr. Ana C. Cristovão, Dr. Márcia C. Neves, Mara G. Freire

doi.org/10.1002/ejic.202000101

Accessing New 5-α-(3,3-Disubstituted Oxindole)-Benzylamine Derivatives from Isatin: Stereoselective Organocatalytic Three Component Petasis Reaction

A simple and mild three-component protocol between 5-arylboronate-3-substituted oxindole derivatives, salicylaldehydes, and secondary amines was established through BINOL-catalyzed Petasis reaction affording new 5-α-(3-substituted-oxindole)-benzylamine derivatives in moderate to excellent yields, moderate to excellent enantio- and diastereoselectivities and good reaction scope.

[Full Papers]

Dr. Carolina S. Marques, Prof. Dr. Patrick McArdle, Prof. Dr. Andrea Erxleben, Prof. Dr. Anthony J. Burke

doi.org/10.1002/ejoc.202000334

CICECO-Aveiro Institute of Materials: A Journey into the Future

Guest Editor João Rocha introduces the CICECO-Aveiro Institute of Materials, summarizing its development from its foundation in 2002 up to the present.

[Guest Editorial]

João Rocha

doi.org/10.1002/ejic.202000475

Redox-Polymer-Wired [NiFeSe] Hydrogenase Variants with Enhanced O2 Stability for Triple-Protected High-Current-Density H2-Oxidation Bioanodes

Triple protection : A stable, high-current-density-based H2-oxidation bioanode is presented. It is equipped with [NiFeSe] variants that show enhanced O2 tolerance, which are immobilized and wired to electrode surfaces with a low-potential viologen-modified polymer. The polymer acts simultaneously as a high-potential and O2 shield. The triply protected bioanodes are incorporated in membrane-free biofuel cells, which reveal benchmark performances at moderate catalyst loading.

[Full Papers]

Dr. Adrian Ruff, Julian Szczesny, Maria Vega, Dr. Sonia Zacarias, Dr. Pedro M. Matias, Dr. Sébastien Gounel, Dr. Nicolas Mano, Prof. Dr. Inês A. C. Pereira, Prof. Dr. Wolfgang Schuhmann

doi.org/10.1002/cssc.202000999

Electroactive Organic Building Blocks for the Chemical Design of Functional Porous Frameworks (MOFs and COFs) in Electronics

Electroactive organic molecules have emerged as promising building blocks for the design of crystalline porous frameworks such as metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) with numerous functions in electronics. This Review provides a library of electroactive organic building blocks recently employed in the construction of functional porous materials with applications in electronics.

[Reviews]

Dr. Manuel Souto, Dr. Karol Strutyński, Dr. Manuel Melle-Franco, Prof. João Rocha

doi.org/10.1002/chem.202001211

Lignin from Tree Barks: Chemical Structure and Valorization

Bark for good : Tree barks are low-cost and abundant lignocellulosic wastes produced by the wood industries. This study concerns the detailed structural characterization of lignin from different tree barks, which will be of great help for the development of efficient conversion technologies of these materials and will aid in their full valorization. The results indicate that bark lignins are a promising source of valuable phenolic compounds.

[Full Papers]

Duarte M. Neiva, Dr. Jorge Rencoret, Dr. Gisela Marques, Prof. Ana Gutiérrez, Prof. Jorge Gominho, Prof. Helena Pereira, Prof. José C. del Río

doi.org/10.1002/cssc.202000431

Cytotoxicity of Platinum and Palladium Chelates against Osteosarcoma

First cytotoxicity assessment of oxaliplatin (OXA) and Pd2/Pt2Spermine (Spm) in osteosarcoma, compared to cisplatin (cDDP). IC50 results from cell viability and cell density assays followed the trend: cDDP≈Pd2Spm<OXA<Pt2Spm, unveiling Pd2Spm as a potential drug for osteosarcoma. Drug combination protocols tends to improve chelates cytotoxicity in general.

[Full Papers]

Ana S. Martins, Dr. Ana L.M. Batista de Carvalho, Dr. Inês Lamego, Prof. M.▪ Paula. M. Marques, Prof. Ana M. Gil

doi.org/10.1002/slct.202001361

A Sweet Galactose Transfer: Metabolic Oligosaccharide Engineering as a Tool To Study Glycans in Plasmodium Infection

Plasmodium glycobiology : The use of artificial galactose derivatives and labelling through iEDDA reaction in the liver stage of Plasmodium infection showed increased uptake in infected hepatic cells, through participation of GLUT1 transporters. Furthermore, unprotected derivatives are transferred from the mosquito host to the Plasmodium berghei parasite. This strategy has the potential to provide new insights into Plasmodium glycobiology.

[Full Papers]

Annabel Kitowski, Dr. Gonçalo J. L. Bernardes

doi.org/10.1002/cbic.202000226

Solution Combustion Synthesis: Towards a Sustainable Approach for Metal Oxides

SCS : Solution combustion synthesis (SCS) is a low cost, simple, fast and energy efficient method to produce oxides with desired morphology. The final properties of the oxide materials can be fine-tuned by controlling crucial parameters (fuel type, metal precursors, stoichiometry, pH). The growing application of printed metal oxide thin films at low temperature in electronic devices is a clear evidence that SCS is a vital step for next-generation large-scale electronics (see figure).

[Reviews]

Emanuel Carlos, Prof. Rodrigo Martins, Prof. Elvira Fortunato, Prof. Rita Branquinho

doi.org/10.1002/chem.202000678