Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic principles, Analytical Examples and Challenges Towards Commercialization for Assays of Protein Cancer Biomarkers

Impedimetric biosensors: The review article provides mechanistic principles behind electrochemical impedance spectroscopy with discussion about the limitation of the detection principle. The final part of the review highlights analytical examples for detection of several tumor biomarkers with analytical characteristics of such biosensors provided.


Dr. Tomas Bertok, Dr. Lenka Lorencova, Erika Chocholova, Dr. Eduard Jane, Dr. Alica Vikartovska, Dr. Peter Kasak, Dr. Jan Tkac


Oxide-Supported Gold Clusters and Nanoparticles in Catalysis: A Computational Chemistry Perspective

New look at gold: This review aims at describing the long-lasting effort of the computational chemists toward a detailed and accurate description of the outstanding catalytic properties of oxide-supported gold nanoparticles. Both methodological aspects and examples of applications are discussed, starting from the description of free-standing Au clusters to their interaction with various metal oxide surfaces and to the study of their catalytic properties in reactions such as CO oxidation or water gas shift.


Dr. Sergio Tosoni, Prof. Gianfranco Pacchioni


Molecular Photoswitching Aided by Excited-State Aromaticity

High quantum yields and fast response times are desirable features of molecular photoswitches in optoelectronics. The switches are often based on E/Z photoisomerization or photoinduced H-atom/proton transfer reactions, whereby it is of interest to develop new strategies to facilitate such reactions. This minireview describes how recent computational studies have discovered that the concept of excited-state aromaticity is crucial to these endeavors.


Assoc. Prof. Bo Durbeej, Dr. Jun Wang, Dr. Baswanth Oruganti


Exploring Factors for the Design of Nanoparticles as Drug Delivery Vectors

Spoilt for choice: When employing nanoparticles in biomedical fields as drug delivery vectors, choosing the right type of nanoparticle and determining the correct procedure for drug loading are critical. In this Minireview, physicochemical factors for nanoparticle choice are reviewed with special emphasis placed on drug loading methods.


Prof. Paula M. Castillo, Dr. Aila Jimenez-Ruiz, Dr. Jose M. Carnerero, Prof. Rafael Prado-Gotor


Hydrogenation of Inorganic Metal Carbonates: A Review on Its Potential for Carbon Dioxide Utilization and Emission Reduction

Mining minerals: Hydrogenation of inorganic metal carbonates opens up a new pathway for processing several metal carbonates. This review summarizes the most important findings and fields of the application of metal carbonate hydrogenation to elucidate the need for a detailed investigation into optimized process conditions for large-scale applications.


Prof. Susanne Lux, Dr. Georg Baldauf-Sommerbauer, Prof. Matthäus Siebenhofer


Extending Designed Linear Biocatalytic Cascades for Organic Synthesis

Chasing waterfalls! Artificial cascades involving biocatalysts are selected from the last year and are classified. The recent examples showed, that even combinations of in vivo as well as in vitro cascades are possible. Incompatible reaction steps may be run in a sequential fashion or by compartmentalisation of the incompatible steps.


Dr. Somayyeh Gandomkar, Dr. Anna Żądło-Dobrowolska, Prof. Dr. Wolfgang Kroutil


When Crystals Go Nano - The Role of Advanced X-ray Total Scattering Methods in Nanotechnology

Nanocrystallography tools, based on wide-angle total scattering techniques and on the Debye Scattering Equation, enable frontier characterization of structure, size, morphology, and defectiveness of nanopowders and colloids.


Federica Bertolotti, Daniele Moscheni, Antonietta Guagliardi, Norberto Masciocchi


Site-Selective C-H Bond Activation/Functionalization of Alpha-Amino Acids and Peptide-Like Derivatives

This review provides the current state of the art on site-selective C-H bond functionalization applied on α-amino acids and peptides, focusing on the different C-H positions that can successfully be addressed to date. Examples at the α-C-H of the peptide backbone and C-H of the side-chains, as well as late stage derivatization of complex peptides, are presented.


Tobias Brandhofer, Olga García Mancheño


Metal-Catalyzed C-H Functionalization Processes with “Click”-Triazole Assistance

Click&Go! Recent advances in the use of 1,2,3-triazoles as versatile directing groups in C-H functionalization are reviewed. The main feature is the straightforward, modular assembly of the required triazoles in “click” fashion, making the procedures practical synthetic tools of key importance for late-stage diversification of “click compounds” - prevalent moieties in drug discovery and materials science.


Itziar Guerrero, Arkaitz Correa


Interfacial Chemistry of Low-Dimensional Systems for Applications in Nanocatalysis

Interfaces exhibit unusual properties that are very different form the parent materials. This special behavior can be traced back to a variety of phenomena such as electron tunneling, charge exchange, and electron hybridization.


Stefano Agnoli


Structural Knowledge for Molecular Optimization: The Cases of Metal-Mediated Protein-Protein Interactions and Structural Vaccinology

Structural biology is a key approach for understanding molecular recognition and for designing optimized, tailored molecules. Two examples are here presented: the optimization or the prevention of molecular recognition patterns between proteins in metal-mediated interactions, and the detailed description of antigen-antibody interactions exploited for the optimization of vaccine antigens.


Francesca Cantini, Lucia Banci


Tristriazolotriazines: Luminescent Discotic Liquid Crystals

The planar tetracyclic tristriazolotriazines are a new group of mesogens for discotic liquid crystals. Their Synthesis, chemical properties, structures of molecules and mesophases, optical and thermal characteristics are reported. The thermal rearrangement converts paddle-wheel type tristriazolotriazines to those with a propeller shape.


Heiner Detert


In Situ Electrochemical Impedance Spectroscopy Measurements and Their Interpretation for the Diagnostic of Metallic Cultural Heritage: A Review

Electrochemistry to save metallic heritage: A comprehensive and critical review of the use of electrochemical impedance spectroscopy as a diagnostic tool for cultural heritage is presented, focusing on different experimental approaches for in situ applications and on the understanding of the results from heritage metal objects, to bring this technique closer to metal conservators and conservation scientist.


Blanca Ramírez Barat, Dr. Emilio Cano


From Chemical Serendipity to Translational Chemistry: New Findings in the Reactivity of Palladacycles

Box of surprises: Serendipitous discoveries have long-since been at the heart of the new advancements in science, and more often than not they provide striking findings that exceed the most promising expectations; thus, serendipity emerges to extend the frontiers of chemistry one step further. Palladacycles have not been strangers to this issue and, herein, some distinguished disclosures are depicted where serendipity yielded remarkable, yet not sought, results.


Dr. Adolfo Fernández-Figueiras, Fátima Lucio-Martínez, Paula Munín-Cruz, Dr. Juan M. Ortigueira, Dr. Paula Polo-Ces, Francisco Reigosa, Prof. Dr. M. Teresa Pereira, Prof. Dr. José M. Vila


Constructing Organometallic Architectures from Aminoalkylidyne Diiron Complexes

Diiron aminoalkylidyne complexes, containing cyclopentadienyl and carbonyl co-ligands, are useful platforms to build uncommon organometallic structures, by assembling molecular fragments via sequential regio- and stereoselective reactions, assisted by cooperative effects and the possibility of multisite coordination provided by the two adjacent metal centers.


Fabio Marchetti


Peripherally Metalated Porphyrins with Applications in Catalysis, Molecular Electronics and Biomedicine

See the future of porphyrin-metal conjugates: Appending transition metal complexes to the periphery of porphyrins, renowned for their photo- and electro-activity, opens new avenues for applications in electron- or photon-triggered catalytic reactions, optoelectronic properties of self-assembled materials, and therapeutic or diagnostic tools in biomedicine.


Dr. Jean-François Longevial, Dr. Sébastien Clément, Dr. Jennifer A. Wytko, Dr. Romain Ruppert, Dr. Jean Weiss, Dr. Sébastien Richeter


Progress in Lanthionine and Protected Lanthionine Synthesis

Non-standard amino acid lanthionine, discovered through hydrolysis of wool, is mainly found in the family of cyclic peptide antibiotics called lantibiotics. Laboratory preparation of these bioactive compounds displaying interesting properties require efficient lanthionine synthesis. This review summarizes the chemical routes to lanthionine from multiple precursors, disclosing the experimental data and analysing the advantage and disadvantage of each method.


Dr. Thibaut Denoël, Dr. Christian Lemaire, Prof. Dr. André Luxen


Progress in Developing a Structure-Activity Relationship for the Direct Aromatization of Methane

Direct Aromatization of Methane: This article is an up-to-date look on research regarding the structure-activity-relationship of the zeolite based catalyst for the methane dehydroaromatization (MDA) reaction. Recent findings from MDA research are summarized and compared to spectroscopic studies and discoveries for similar catalytic systems. The review aims to both give a better understanding of the structure-activity relationship for the MDA catalyst and to inspire further studies on this topic.


Ina Vollmer, Dr. Irina Yarulina, Prof. Freek Kapteijn, Prof. Jorge Gascon


Glycosylation: The Direct Synthesis of 2-Acetamido-2-Deoxy-Sugar Glycosides

This microreview details the direct but arduous approaches for the synthesis of glycosides in which the NHAc group is present during the glycosylation reaction.


Jean-Marie Beau, François-Didier Boyer, Stéphanie Norsikian, Dominique Urban, Boris Vauzeilles, Amandine Xolin


Tailoring Sensitivity in Electrochemical Nucleic Acid Hybridization Biosensing: Role of Surface Chemistry and Labeling Strategies

Hybridising electrochemistry and biosensing: Simple and rapid strategies to tailor the sensitivity in electrochemical nucleic acid biosensing involving both, tackling a judicious design of the surface chemistry or simply varying the bioassay format, hybrid length and labeling strategy.


Prof. Susana Campuzano, Prof. Paloma Yáñez-Sedeño, Prof. José Manuel Pingarrón


Homogeneous Catalytic Reduction of CO2 with Silicon-Hydrides, State of the Art

From silicon valley to silicon hydrides: Catalytic reduction of CO2 with silicon-hydrides could be considered as a promising and emerging chemical methodology.


Dr. Francisco J. Fernández-Alvarez, Prof. Luis A. Oro


Boron Nitride for Hydrogen Storage

Boron nitride, BN (in the form of nanostructures), is a promising candidate for the deployment of the near-future “hydrogen economy” owing to its ability to reversibly physisorb and chemisorb molecular hydrogen, H2. The adsorption process attractively takes place at room temperature. Nevertheless, further efforts are still required to tune the sorption properties towards optimization.


Dr. Abhijeet Lale, Dr. Samuel Bernard, Prof. Umit B. Demirci


Heteroarene N-Oxides as Oxygen Source in Organic Reactions

Heteroarene N-oxides can be used as transfer oxygenation agents in organic synthesis. The application of N-oxides as mild oxygen source for the oxygenation of aliphatic and aromatic hydrocarbons as well as unsaturated substrates is reviewed.


Andranik Petrosyan, Richy Hauptmann, Jola Pospech


Recent Advances in [Cp*MIII] (M = Co, Rh, Ir)-Catalyzed Intramolecular Annulation Through C-H Activation

This review highlights recent catalytic methods using Cp*MIII complexes (M = Co, Rh, Ir) as catalysts for C-H activation followed by intramolecular reactions. In this overview of the literature, attention is given to the nature of the coupling partners and their connections either to the aryl (or vinyl) group, or to the directing group.


Augustin Peneau, Catherine Guillou, Laurent Chabaud


Hydrozirconation of C=X Functionalities with Schwartz's Reagent


Michał M. Więcław, Sebastian Stecko