The Effect of Ambient Carbon Dioxide on Anion-Exchange Membrane Fuel Cells

The Effect of Ambient Carbon Dioxide on Anion‐Exchange Membrane Fuel Cells

Effect of fresh air: Experimental and theoretical studies reported in the literature on the effect of ambient CO2 on anion-exchange membrane fuel cells (AEMFCs) are reviewed. This Review aims to create a single, comprehensive account of what is known regarding how CO2 behaves in AEMFCs, to date, as well as identify the most important areas for future work in this field.

[Review]
Noga Ziv, William E. Mustain, Dario R. Dekel
ChemSusChem, March 15, 2018, https://doi.org/10.1002/cssc.201702330 Read article

Circularly Polarized Luminescence and Circular Dichroisms in Small Organic Molecules: Correlation between Excitation and Emission Dissymmetry Factors

Circularly Polarized Luminescence and Circular Dichroisms in Small Organic Molecules: Correlation between Excitation and Emission Dissymmetry Factors

Another view: The absorption and luminescence dissymmetry factors (gabs and glum) of the π–π* transition of chiral organic molecules of various categories, including planar chiral cyclophanes and helicenes, axially chiral biaryls and spiro compounds, were analyzed quantitatively. It was found that in general the circularly polarized luminescence (CPL) dissymmetry factor is proportional to, and smaller than, the circular dichroism (CD) dissymmetry factor.

[Review]
Hiroki Tanaka, Yoshihisa Inoue, Tadashi Mori
ChemPhotoChem, March 15, 2018, https://doi.org/10.1002/cptc.201800015 Read article

Metal Catalysts for the Efficient Transformation of Biomass-derived HMF and Furfural to Value Added Chemicals

Metal Catalysts for the Efficient Transformation of Biomass‐derived HMF and Furfural to Value Added Chemicals

Value rising: In this Review, we provided an up-to-date comprehensive overview on a wide collection of heterogeneous catalysts explored for the prominent catalytic transformations of biomass-derived furans (furfural and HMF) to value-added chemicals and fuel component following various processes such as hydrogenation, decarbonylation, oxidation, hydrogenolysis and furan ring opening. This Review elaborated in details the key role of catalysts in these diverse upgrading processes and the mechanistic pathways for biomass transformation.

[Review]
Kavita Gupta, Rohit K. Rai, Sanjay K. Singh
ChemCatChem, March 15, 2018, https://doi.org/10.1002/cctc.201701754 Read article

Covalent Triazine-based Frameworks—Tailor-made Catalysts and Catalyst Supports for Molecular and Nanoparticulate Species

Covalent Triazine‐based Frameworks—Tailor‐made Catalysts and Catalyst Supports for Molecular and Nanoparticulate Species

Tailor-made catalysts: Covalent triazine-based frameworks represent a fascinating material class, suitable as catalysts and catalyst supports for both molecular and nanoparticulate species. This Minireview seeks to outline the most recent developments regarding synthesis, characteristics and catalytic applications as well as current challenges for this material class.

[Minireview]
Jens Artz
ChemCatChem, March 14, 2018, https://doi.org/10.1002/cctc.201701820 Read article

Lignocellulose Liquefaction to Biocrude: A Tutorial Review

Lignocellulose Liquefaction to Biocrude: A Tutorial Review

Finally—large scale production: After decades of research and development, biomass liquefaction is now being applied on a 200–3000 tons per year scale to produce biocrudes for use as heavy fuel or for upgrading to biofuels. This Review presents the various facets of the liquefaction process, from chemistry to product to technology, in a tutorial manner.

[Review]
Jean-Paul Lange
ChemSusChem, March 13, 2018, https://doi.org/10.1002/cssc.201702362 Read article

Radicals and Sulfur Dioxide: A Versatile Combination for the Construction of Sulfonyl-Containing Molecules

Radicals and Sulfur Dioxide: A Versatile Combination for the Construction of Sulfonyl‐Containing Molecules

Radical-based transformations with sulfur dioxide have emerged as attractive new tool for the synthesis of sulfones, sulfonamides or sulfonyl chlroides. This minireview covers the historical background and recent progress in this area.

[Minireview]
Kamil Hofman, Nai-Wei Liu, Georg Manolikakes
Chem. Eur. J., March 13, 2018, https://doi.org/10.1002/chem.201705470 Read article

Chemical and Enzymatic Strategies for Bacterial and Mammalian Cell Surface Engineering

Chemical and Enzymatic Strategies for Bacterial and Mammalian Cell Surface Engineering

The cell surface serves important functions such as the regulation of cell-cell and cell-environment interactions. The understanding and manipulation of the cell surface is important for a wide range of fundamental studies and therapeutic applications. Here, we review the recent development of chemical and enzymatic approaches to cell surface engineering with particular emphasis on discussing the advantages and limitations of each of these strategies.

[Minireview]
Xiaobao Bi, Juan Yin, Ashley Chen Guanbang, Chuan-Fa Liu
Chem. Eur. J., March 13, 2018, https://doi.org/10.1002/chem.201705049 Read article

POM & MOF-based Electrocatalysts for Energy-related Reactions

POM & MOF‐based Electrocatalysts for Energy‐related Reactions

Energy for humanity: A global-scale sustainable energy system, based in renewable energy storage and conversion technologies, is crucial for the future of humanity. POM- & MOF-based materials are promising electrocatalysts for the energy-related electrochemical reactions (oxygen reduction and evolution reactions and hydrogen evolution reaction).

[Review]
Cristina Freire, Diana M. Fernandes, Marta Nunes, Victor K. Abdelkader
ChemCatChem, March 13, 2018, https://doi.org/10.1002/cctc.201701926 Read article

Iron Carbides and Nitrides: Ancient Materials with Novel Prospects

Iron Carbides and Nitrides: Ancient Materials with Novel Prospects

Hard as iron: Known to all, iron carbides and nitrides, a series of particular structures with complex bond interactions, have attracted much attention due to excellent mechanical, magnetic and catalytic properties. Furthermore, nanocomposite materials associated with iron carbide and nitride have been used in biomedical, electrochemical catalysis, energy storage, and other fields and have shown extraordinary performance. This article summarizes the structure, synthesis, and application of iron carbides and nitrides.

[Review]
Zhantong Ye, Peng Zhang, Xiang Lei, Xiaobai Wang, Nan Zhao, Hua Yang
Chem. Eur. J., March 12, 2018, https://doi.org/10.1002/chem.201706028 Read article

Access to 1,1-Diborylalkenes and Concomitant Stereoselective Reactivity

Access to 1,1‐Diborylalkenes and Concomitant Stereoselective Reactivity

[Microreview]
Jordi Royes, Ana B. Cuenca, Elena Fernández
Eur. J. Org. Chem., March 08, 2018, https://doi.org/10.1002/ejoc.201701786 Read article

Advances in the Synthesis and Application of Tetrafluoroethylene- and 1,1,2,2-Tetrafluoroethyl-Containing Compounds

Advances in the Synthesis and Application of Tetrafluoroethylene‐ and 1,1,2,2‐Tetrafluoroethyl‐Containing Compounds

[Microreview]
Jiří Václavík, Iveta Klimánková, Alena Budinská, Petr Beier
Eur. J. Org. Chem., March 08, 2018, https://doi.org/10.1002/ejoc.201701590 Read article

Interrogating Protein Phosphatases with Chemical Activity Probes

Interrogating Protein Phosphatases with Chemical Activity Probes

Illuminating Protein Phosphatases: Protein phosphatases are becoming recognized as critical signaling enzymes in both normal and disease physiology. Chemical reporters of enzymatic activity are poised to provide insights into the chemical biology of these important signaling enzymes.

[Minireview]
Garrett R. Casey, Cliff I. Stains
Chem. Eur. J., March 08, 2018, https://doi.org/10.1002/chem.201705194 Read article

Controlling Selectivity in Aliphatic C−H Oxidation through Supramolecular Recognition

Controlling Selectivity in Aliphatic C−H Oxidation through Supramolecular Recognition

The use of supramolecular interactions to bind and orient the substrate can unlock novel selectivities in C−H oxidation. In this Minireview different, bioinspired strategies towards this goal are discussed.

[Minireview]
Diego Vidal, Giorgio Olivo, Miquel Costas
Chem. Eur. J., March 08, 2018, https://doi.org/10.1002/chem.201704852 Read article

The Role of Copper in the Upgrading of Bioalcohols

The Role of Copper in the Upgrading of Bioalcohols

Recent results on Guerbet reactions and dehydrogenative coupling of alcohols (DHC) show that fine tuning of the catalyst acidic and basic sites can lead to Guerbet products with high selectivity, whereas the presence of Cu leads to the activation of the carbonyl group toward nucleophilic attack by a second molecule of alcohol, thus giving the symmetric ester.

[Minireview]
Federica Zaccheria, Nicola Scotti, Nicoletta Ravasio
ChemCatChem, March 08, 2018, https://doi.org/10.1002/cctc.201701844 Read article

Application of Mono- and Disaccharides in Drug Targeting and Efficacy

Application of Mono‐ and Disaccharides in Drug Targeting and Efficacy

Sweet specificity: This review covers the targeting and efficacy properties of mono- and disaccharides applied in drug design and discovery. The primary structure–activity relationships derived from biological evaluations of subtle structural variations in mono- or disaccharides and their binding affinities for proteins of interest are emphasized and discussed; this should provide helpful guidelines for the design of new saccharide-based targeted agents.

[Minireview]
Si S. Yuan, Mao L. Li, Jian S. Chen, Li Zhou, Wen Zhou
ChemMedChem, March 07, 2018, https://doi.org/10.1002/cmdc.201700762 Read article

Single Ion Magnets from 3d to 5f: Developments and Strategies

Single Ion Magnets from 3d to 5f: Developments and Strategies

How molecular magnetism works: A summary of single-ion magnets (SIMs) including the development of 3d, 5d, 4f, and 5f metal-based SIMs and the possible ligand field strategies for high-performance SIMs constructions.

[Minireview]
Min Feng, Ming-Liang Tong
Chem. Eur. J., March 06, 2018, https://doi.org/10.1002/chem.201705761 Read article

Overview on the Recent Strategies for the Enantioselective Synthesis of 1, 1-Diarylalkanes, Triarylmethanes and Related Molecules Containing the Diarylmethine Stereocenter

Overview on the Recent Strategies for the Enantioselective Synthesis of 1, 1‐Diarylalkanes, Triarylmethanes and Related Molecules Containing the Diarylmethine Stereocenter

The variety of synthetic methodologies available for the enantioselective synthesis of 1, 1-diarylethanes, triarylmethanes and related molecules with a 1, 1-diaryl stereogenic center are discussed in this Review, as there is an increased interest in active pharmaceutical agents that contain this motif. Comparative discussions on the future aspects of the synthesis of these molecules with a short comparison of the different available routes and possible areas of development are also presented.

[Review]
Sankalan Mondal, Deblina Roy, Gautam Panda
ChemCatChem, March 05, 2018, https://doi.org/10.1002/cctc.201701601 Read article

Sol–gel Entrapped Nitroxyl Radicals: Catalysts of Broad Scope

Sol–gel Entrapped Nitroxyl Radicals: Catalysts of Broad Scope

Changing TEMPO: Sol–gel entrapped TEMPO-like radicals are excellent supported molecular catalysts for the selective and clean alcohol oxidation, including the primary hydroxyl functions of cellulose.

[Minireview]
Rosaria Ciriminna, Valerica Pandarus, Francois Béland, Mario Pagliaro
ChemCatChem, March 02, 2018, https://doi.org/10.1002/cctc.201701910 Read article

Understanding the Reactivity of Fullerenes Through the Activation Strain Model

Understanding the Reactivity of Fullerenes Through the Activation Strain Model

This Microreview examines the good performance of the combined Activation Strain Model of reactivity and Energy Decomposition Analysis methods not only in aiding quantitative understanding of fullerenes but also in predicting their reactivity.

[Microreview]
Israel Fernández
Eur. J. Org. Chem., March 01, 2018, https://doi.org/10.1002/ejoc.201701626 Read article

The Controversial Orientation of Adenine on Gold and Silver

The Controversial Orientation of Adenine on Gold and Silver

The adsorption controversy: The adsorption orientation of adenine on gold and silver surfaces has been a matter of debate. The many, and often conflicting, reports of adenine adsorption on nanoparticles, electrodes, and other surfaces are discussed herein.

[Minireview]
Scott G. Harroun
ChemPhysChem, February 28, 2018, https://doi.org/10.1002/cphc.201701223 Read article

Glucagon-Like Peptide-1 (GLP-1)-Based Therapeutics: Current Status and Future Opportunities beyond Type 2 Diabetes

Glucagon‐Like Peptide‐1 (GLP‐1)‐Based Therapeutics: Current Status and Future Opportunities beyond Type 2 Diabetes

Improved treatments for ′diabesity′: Glucagon-like peptide-1 (GLP-1) is an injectable, short half-life treatment for type 2 diabetes and obesity, with many exciting properties such as decreased appetite and cardiovascular protection. This review details current and future approaches to modify GLP-1 to improve its circulation time, metabolic stability, administration route, and dosing schedule.

[Minireview]
Jia Ying Cheang, Peter M. Moyle
ChemMedChem, February 28, 2018, https://doi.org/10.1002/cmdc.201700781 Read article

Radical-Mediated Formal C(sp2)–H Functionalization of Aldehyde-Derived N,N-Dialkylhydrazones

Radical‐Mediated Formal C(sp2)–H Functionalization of Aldehyde‐Derived N,N‐Dialkylhydrazones

[Microreview]
Alexis Prieto, Didier Bouyssi, Nuno Monteiro
Eur. J. Org. Chem., February 27, 2018, https://doi.org/10.1002/ejoc.201701600 Read article

Silica-Supported Molecular Catalysts for Tandem Reactions

Silica‐Supported Molecular Catalysts for Tandem Reactions

In tandem: Tandem reactions catalyzed by silica-supported molecular catalysts are of significant importance in green chemistry owing to their easy recyclability and environmentally benign fashion. This minireview focuses mainly on the constructions of silica-supported molecular catalysts and summarizes the recent advances of sequential organic transformations through tandem reactions.

[Minireview]
Ronghua Jin, Dongsong Zheng, Rui Liu, Guohua Liu
ChemCatChem, February 27, 2018, https://doi.org/10.1002/cctc.201701718 Read article

Recent Advances in Pd-Catalyzed Cross-Coupling Reaction in Ionic Liquids

Recent Advances in Pd‐Catalyzed Cross‐Coupling Reaction in Ionic Liquids

This microreview briefly summarizes the recent developments in Pd-catalyzed cross-coupling in ionic liquids. In addition, we also highlight the synthetic methods, catalytic systems, and mechanisms of selected coupling reactions.

[Microreview]
Jianxiao Li, Shaorong Yang, Wanqing Wu, Huanfeng Jiang
Eur. J. Org. Chem., February 23, 2018, https://doi.org/10.1002/ejoc.201701509 Read article

Recent Progress in Ethylene Polymerization Catalyzed by Ni and Pd Catalysts

Recent Progress in Ethylene Polymerization Catalyzed by Ni and Pd Catalysts

[Microreview]
Jun Wang, Li Wang, Haojie Yu, Raja Summe Ullah, Muhammad Haroon, Zain-ul-Abdin, Xia Xia, Rizwan Ullah Khan
Eur. J. Inorg. Chem., February 23, 2018, https://doi.org/10.1002/ejic.201701336 Read article

Theoretical Studies of Singlet Fission: Searching for Materials and Exploring Mechanisms

Theoretical Studies of Singlet Fission: Searching for Materials and Exploring Mechanisms

Singlet fission (SF) provides an avenue to enhance the photoelectric conversion efficiency in organic photovoltaic devices to exceed the Shockley–Queisser limit. It has become a subject of intense research. Theoretical studies of SF since 2006 are thus reviewed. Electronic structure calculations facilitate designing SF chromophores and improve the understanding of the coupling between single- and multi-excitonic states. Quantum dynamics simulations reveal the importance of vibronic coupling in SF. The accuracy of the theoretical studies is examined by comparing their results with experiments.

[Review]
Achini Japahuge, Tao Zeng
ChemPlusChem, February 23, 2018, https://doi.org/10.1002/cplu.201700489 Read article

Caveat Usor: Assessing Differences between Major Chemistry Databases

Caveat Usor: Assessing Differences between Major Chemistry Databases

The three databases of PubChem, ChemSpider, and UniChem capture the majority of open chemical structure records. Collectively, they constitute a massively enabling resource for cheminformatics, chemical biology, and drug discovery. It is important for users to have at least some appreciation of differential content to enable utility judgments for the tasks at hand. This turns out to be challenging. By comparing the three resources in detail, this review assesses their differences, some of which are not obvious.

[Review]
Christopher Southan
ChemMedChem, February 23, 2018, https://doi.org/10.1002/cmdc.201700724 Read article

Whole-Cell Cascade Biotransformations for One-Pot Multistep Organic Synthesis

Whole‐Cell Cascade Biotransformations for One‐Pot Multistep Organic Synthesis

Bugs for Cascade Catalysis: Recombinant Escherichia coli is easily available and self-replicating whole-cell catalyst for biotransformations. Multiple enzymes could be co-expressed in a single E. coli host, thus enabling facile one-pot synthesis of valuable (chiral) products. In this paper, we reviewed the recent development, provided instruction, and discussed problems and solutions of whole-cell cascade biotransformations.

[Minireview]
Shuke Wu, Zhi Li
ChemCatChem, February 23, 2018, https://doi.org/10.1002/cctc.201701669 Read article

Emergence of Surface- and Interface-Induced Structures and Properties in Metal–Organic Framework Thin Films

Emergence of Surface‐ and Interface‐Induced Structures and Properties in Metal–Organic Framework Thin Films

[Microreview]
Tomoyuki Haraguchi, Kazuya Otsubo, Hiroshi Kitagawa
Eur. J. Inorg. Chem., February 20, 2018, https://doi.org/10.1002/ejic.201701234 Read article

Controlling the Outgrowth and Functions of Neural Stem Cells: The Effect of Surface Topography

Controlling the Outgrowth and Functions of Neural Stem Cells: The Effect of Surface Topography

Neural stem cells (NSCs) are self-renewing cells that generate the major cell types of the central nervous system. The authors review the use of artificial micro- and nano-topographical features to control the orientation of NSCs and their differentiation into neuronal and/or neuroglial lineages.

[Review]
Chara Simitzi, Kanelina Karali, Anthi Ranella, Emmanuel Stratakis
ChemPhysChem, February 19, 2018, https://doi.org/10.1002/cphc.201701175 Read article

Investigating Protein–Ligand Interactions by Solution Nuclear Magnetic Resonance Spectroscopy

Investigating Protein–Ligand Interactions by Solution Nuclear Magnetic Resonance Spectroscopy

Pick your NMR: Protein–ligand interactions are of fundamental importance in almost all processes in living organisms. Solution NMR spectroscopy, which is particularly useful for studying weak interactions, offers a large repertoire of techniques to study ligand complexes, providing information ranging from the simple presence of binding or epitope mapping to the complete 3 D structure of the complex.

[Review]
Walter Becker, Krishna Chaitanya Bhattiprolu, Nina Gubensäk, Klaus Zangger
ChemPhysChem, February 16, 2018, https://doi.org/10.1002/cphc.201701253 Read article

Exploring Structure–Activity Relationships with Three-Dimensional Matched Molecular Pairs—A Review

Exploring Structure–Activity Relationships with Three‐Dimensional Matched Molecular Pairs—A Review

Better in 3D: Exploration of activity cliffs in structure–activity relationship series is an excellent source of new insight. Three-dimensional matched molecular pairs (3D MMP) are an intuitive way to analyze existing data and to build models based on resulting observations. We present a concise summary of models and applications of recent years. Shown is a 3D MMP as published by Posy et al., J. Chem. Inf. Model. 2013, 53, 1576–1588 (reprinted with permission, © 2013 American Chemical Society).

[Minireview]
Emanuel S. R. Ehmki, Matthias Rarey
ChemMedChem, February 09, 2018, https://doi.org/10.1002/cmdc.201700628 Read article

Electrochemistry of Polyoxometalates: From Fundamental Aspects to Applications

Electrochemistry of Polyoxometalates: From Fundamental Aspects to Applications

This review paper addresses electrochemical properties of various polyoxometalates from fundamental and practical points of view

[Review]
Tadaharu Ueda
ChemElectroChem, February 07, 2018, https://doi.org/10.1002/celc.201701170 Read article

Microfabricated Probes for Studying Brain Chemistry: A Review

Microfabricated Probes for Studying Brain Chemistry: A Review

Microfabricated neurochemical probes: Microfabrication technology emerges as an important tool for developing miniature, high precision probes for electrochemical detection and sampling from live brain tissues. This review describes advances and perspectives in adapting microfabrication to create the next generation of neurochemical probes.

[Review]
Thitaphat Ngernsutivorakul, Thomas S. White, Robert T. Kennedy
ChemPhysChem, February 05, 2018, https://doi.org/10.1002/cphc.201701180 Read article

Synthesis of α-(Trifluoromethyl)pyridazine Derivatives

Synthesis of α‐(Trifluoromethyl)pyridazine Derivatives

[Microreview]
Alexandra Feraldi-Xypolia, Domingo Gomez Pardo, Janine Cossy
Eur. J. Org. Chem., February 02, 2018, https://doi.org/10.1002/ejoc.201701412 Read article

Nitrogen Fixation Catalyzed by Transition Metal Complexes: Recent Developments

Nitrogen Fixation Catalyzed by Transition Metal Complexes: Recent Developments

[Microreview]
Nadja Stucke, Benedikt M. Flöser, Thomas Weyrich, Felix Tuczek
Eur. J. Inorg. Chem., February 01, 2018, https://doi.org/10.1002/ejic.201701326 Read article

Phosphasalen vs. Salen Ligands: What Does the Phosphorus Change?

Phosphasalen vs. Salen Ligands: What Does the Phosphorus Change?

Phosphasalen complexes featuring a tetradentate N2O2 ligand can be viewed as the phosphorus analogues of salen, in which iminophosphoranes (P=N) replace imines. The presence of the phosphorus influences both the electronic properties and the steric hindrance. This was demonstrated by studies on the electronic structure of one-electron oxidized complexes, as well as the catalytic abilities of phosphasalen complexes in ROP reactions.

[Microreview]
Irene Mustieles Marín, Audrey Auffrant
Eur. J. Inorg. Chem., January 25, 2018, https://doi.org/10.1002/ejic.201701210 Read article

Hydrozirconation of C=X Functionalities with Schwartz's Reagent

Hydrozirconation of C=X Functionalities with Schwartz's Reagent

This Microreview covers the reactions of [Cp2Zr(H)Cl] with C=X functionalities, such as amides, lactams, nitriles or isocyanates, as a method for chemoselective preparation of functionalized organic molecules, for instance aldehydes, amines, and amides.

[Microreview]
Michał M. Więcław, Sebastian Stecko
Eur. J. Org. Chem., January 19, 2018, https://doi.org/10.1002/ejoc.201701537 Read article

Diaminoterephthalate Fluorescence Dyes – Versatile Tools for Life Sciences and Materials Science

Diaminoterephthalate Fluorescence Dyes – Versatile Tools for Life Sciences and Materials Science

The diaminoterephthalate chromophore defines a fluorescent scaffold being facilely equipped with different functional units (FU) starting from orthogonally protected succinyl succinates.

[Microreview]
Jens Christoffers
Eur. J. Org. Chem., January 11, 2018, https://doi.org/10.1002/ejoc.201701447 Read article

Optical Techniques for Light-Emitting Electrochemical Cells

Optical Techniques for Light‐Emitting Electrochemical Cells

Show me the light: Recently, optical techniques, including light extraction, recombination zone probing and spectral filtering based on the microcavity effect and localized surface plasmon resonance from metal nanoparticles, have been shown to improve the performance of light-emitting electrochemical cells. This Minireview provides an overview of these novel optical techniques.

[Minireview]
Hai-Ching Su
ChemPlusChem, January 03, 2018, https://doi.org/10.1002/cplu.201700455 Read article

Strategies toward Long-Life Light-Emitting Electrochemical Cells

Strategies toward Long‐Life Light‐Emitting Electrochemical Cells

Life extension: How can the operational lifetime of light-emitting electrochemical cells (LECs) be extended? A survey of the literature data points to clear trends, as well as some unexpected results in LECs, including polymer-based LECs (PLECs), that are stressed for extended periods (details of some long-life PLECs shown in the figure). Major challenges still exist, but long-lasting LECs are possible when the proven strategies are combined with innovative materials and device design.

[Minireview]
Jun Gao
ChemPlusChem, December 29, 2017, https://doi.org/10.1002/cplu.201700461 Read article

Synthetic Oligosaccharide Libraries and Microarray Technology: A Powerful Combination for the Success of Current Glycosaminoglycan Interactomics

Synthetic Oligosaccharide Libraries and Microarray Technology: A Powerful Combination for the Success of Current Glycosaminoglycan Interactomics

The combination of synthetic glycosaminoglycan (GAG) oligosaccharides and microarray technology has played a pivotal role in our understanding of GAG interactomics. Synthetic GAG libraries have been created by chemoenzymatic or de novo synthesis. Glycan microarrays based on these oligosaccharides have been used to assess GAG specificities and affinities of various GAG-binding proteins. This powerful combination has allowed significant progress in deciphering the intricacies of GAG–protein interactions.

[Review]
Vitor H. Pomin, Xu Wang
ChemMedChem, December 06, 2017, https://doi.org/10.1002/cmdc.201700620 Read article